Osteomyelitis is a devastating disease caused by microbial infection of bone. While the
frequency of infection following elective orthopedic surgery is low, rates of reinfection are …

Staphylococcus aureus bacteremia (SAB) is an important infection with an incidence rate
ranging from 20 to 50 cases/100,000 population per year. Between 10% and 30% of these …

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In apparent contrast to its invasive potential Staphylococcus aureus colonizes the anterior
nares of 20–80% of the human population. The relationship between host and microbe …

Abstract Purpose of Review Staphylococcus aureus is the primary pathogen responsible for
osteomyelitis, which remains a major healthcare burden. To understand its dominance, here …

Abstract Purpose of Review The incidence of complications from prosthetic joint infection
(PJI) is increasing, and treatment failure remains high. We review the current literature with a …

Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain
elusive. While the importance of cellular immunity has been shown in mice, T cell responses …

This review considers the reasons why the staphylococcal vaccine trials may have failed,
based on new information about protective immunity against Staphylococcus aureus. The …

Although many microbial infections elicit an adaptive immune response that can protect
against reinfection, it is generally thought that Staphylococcus aureus infections fail to …

Background: Unicompartmental knee arthroplasty is a less-invasive alternative to total knee
arthroplasty for patients with arthritis affecting only the medial or lateral compartment …