Traumatic brain injury and risk of neurodegenerative disorder
Traumatic brain injury (TBI), particularly of greater severity (ie, moderate to severe), has
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …
[HTML][HTML] Calcium permeable-AMPA receptors and excitotoxicity in neurological disorders
C Guo, YY Ma - Frontiers in neural circuits, 2021 - frontiersin.org
Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the
central and peripheral nervous systems. Other than the previously established signaling …
central and peripheral nervous systems. Other than the previously established signaling …
Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia
KG Witcher, CE Bray, T Chunchai, F Zhao… - Journal of …, 2021 - Soc Neuroscience
Traumatic brain injury (TBI) can lead to significant neuropsychiatric problems and
neurodegenerative pathologies, which develop and persist years after injury …
neurodegenerative pathologies, which develop and persist years after injury …
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early-and late-phase COVID-19
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …
STING trafficking as a new dimension of immune signaling
D Jeltema, K Abbott, N Yan - Journal of Experimental Medicine, 2023 - rupress.org
The cGAS–STING pathway is an evolutionarily conserved immune signaling pathway critical
for microbial defense. Unlike other innate immune pathways that largely rely on stationary …
for microbial defense. Unlike other innate immune pathways that largely rely on stationary …
Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes
N Hegdekar, C Sarkar, S Bustos, RM Ritzel… - Autophagy, 2023 - Taylor & Francis
Excessive and prolonged neuroinflammation following traumatic brain injury (TBI)
contributes to long-term tissue damage and poor functional outcomes. However, the …
contributes to long-term tissue damage and poor functional outcomes. However, the …
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature
Cerebrovascular injury (CVI) is a common pathology caused by infections, injury, stroke,
neurodegeneration and autoimmune disease. Rapid resolution of a CVI requires a …
neurodegeneration and autoimmune disease. Rapid resolution of a CVI requires a …
Amplified gliosis and interferon-associated inflammation in the aging brain following diffuse traumatic brain injury
Traumatic brain injury (TBI) is associated with chronic psychiatric complications and
increased risk for development of neurodegenerative pathology. Aged individuals account …
increased risk for development of neurodegenerative pathology. Aged individuals account …
The meningeal transcriptional response to traumatic brain injury and aging
Emerging evidence suggests that the meningeal compartment plays instrumental roles in
various neurological disorders, however, we still lack fundamental knowledge about …
various neurological disorders, however, we still lack fundamental knowledge about …
[HTML][HTML] Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon response
BP Todd, MS Chimenti, Z Luo, PJ Ferguson… - Journal of …, 2021 - Springer
Background Traumatic brain injury (TBI) is a leading cause of death and disability that lacks
neuroprotective therapies. Following a TBI, secondary injury response pathways are …
neuroprotective therapies. Following a TBI, secondary injury response pathways are …