Drug toxicity evaluation is an essential process of drug development as it is reportedly
responsible for the attrition of approximately 30% of drug candidates. The rapid increase in …

Abstract The Open Targets Platform (https://www. targetvalidation. org/) provides users with
a queryable knowledgebase and user interface to aid systematic target identification and …

Various sources of information can be used to better understand and predict compound
activity and safety-related endpoints, including biological data such as gene expression and …

Schistosome parasites kill 250,000 people every year. Treatment of schistosomiasis relies
on the drug praziquantel. Unfortunately, a scarcity of molecular tools has hindered the …

Next generation risk assessment (NGRA) is an exposure-led, hypothesis-driven approach
that has the potential to support animal-free safety decision-making. However, significant …

Current gaps in drug safety sciences can result from the inability (1) to identify hazard across
multiple target organs,(2) to predict and risk assess with certainty against drug safety …

Most small molecule drugs interact with unintended, often unknown, biological targets and
these off-target interactions may lead to both preclinical and clinical toxic events. Undesired …

Abstract Background Adverse drug reactions (ADRs) are one of the leading causes of
morbidity and mortality in health care. Understanding which drug targets are linked to ADRs …

Background Several factors contribute to the development failure of novel pharmaceuticals,
one of the most important being adverse effects in pre-clinical and clinical studies. Early …

Small-molecule (SM) leads in the early drug discovery pipeline are progressed primarily
based on potency against the intended target (s) and selectivity against a very narrow slice …