Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by
prokaryotes and eukaryotes alike to control cell fate and generate cell diversity. A detailed …

How to adapt to a changing environment is a fundamental, recurrent problem confronting
cells. One solution is for cells to organize their constituents into a limited number of spatially …

During mammalian development, the first asymmetric cell divisions segregate cells into
inner and outer positions of the embryo to establish the pluripotent and trophectoderm …

During Drosophila melanogaster male germline stem cell (GSC) asymmetric division,
preexisting old versus newly synthesized histones H3 and H4 are asymmetrically inherited …

Robust brain development requires the tight coordination between tissue growth, neuronal
differentiation and stem cell maintenance. To achieve this, neural stem cells need to balance …

Gametogenesis produces the only cell type within a metazoan that contributes both genetic
and epigenetic information to the offspring. Extensive epigenetic dynamics are required to …

Asymmetric cell division produces two cells that are genetically identical but each have
distinctly different cell fates. During this process, epigenetic mechanisms play an important …

The discovery of biased histone inheritance in asymmetrically dividing Drosophila
melanogaster male germline stem cells demonstrates one means to produce two distinct …

Gametogenesis is one of the most extreme cellular differentiation processes that takes place
in Drosophila male and female germlines. This process begins at the germline stem cell …

Centromeres are epigenetically defined by CENP-A–containing chromatin and are essential
for cell division. Previous studies suggest asymmetric inheritance of centromeric proteins …