Using the comet and micronucleus assays for genotoxicity studies: A review

RP Araldi, TC de Melo, TB Mendes… - Biomedicine & …, 2015 - Elsevier
Physical, chemical and biological agents can act in the DNA, resulting in mutation involved
in cancer. Thus, genotoxic tests are required by regulatory agencies in order to evaluate …

The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment

SEM Lewis, RJ Aitken, SJ Conner, G De Iuliis… - Reproductive …, 2013 - Elsevier
Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of
assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo …

[HTML][HTML] Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic

JE Chavarro, TL Toth, DL Wright, JD Meeker… - Fertility and sterility, 2010 - Elsevier
OBJECTIVE: To examine the association between body weight and measures of male
reproductive potential. DESIGN: Cross-sectional study. SETTING: Fertility clinic in an …

Insulin dependant diabetes mellitus: implications for male reproductive function

IM Agbaje, DA Rogers, CM McVicar… - Human …, 2007 - academic.oup.com
BACKGROUND Diabetes mellitus (DM) is increasing in men of reproductive age. Despite
this, the prevalence of diabetes in men attending fertility clinics is largely unknown …

Sperm morphology: assessment, pathophysiology, clinical relevance, and state of the art in 2017

N Gatimel, J Moreau, J Parinaud, RD Léandri - Andrology, 2017 - Wiley Online Library
For over 30 years, sperm morphology assessment has been one of the most common tests
in evaluation of fertility. This review examines the clinical relevance of sperm morphology …

[HTML][HTML] Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis

M Cocuzza, SC Sikka, KS Athayde… - International braz j urol, 2007 - SciELO Brasil
Oxidative stress (OS) in the reproductive tract is now a real entity and concern due to the
potential harmful effects of high levels of reactive oxygen species (ROS) on sperm number …

Clinical aspects of sperm DNA fragmentation detection and male infertility

DP Evenson, R Wixon - Theriogenology, 2006 - Elsevier
Over the past 25 years, various methods have been developed to measure sperm DNA
strand breaks in situ. Currently, there are four major tests of sperm DNA fragmentation …

How to overcome male infertility after 40: Influence of paternal age on fertility

S Belloc, A Hazout, A Zini, P Merviel, R Cabry… - Maturitas, 2014 - Elsevier
The recent trend toward delayed parenthood raises major safety concerns because of the
adverse effects of aging on couple fertility. Studies have demonstrated that aging clearly …

[HTML][HTML] Age-related decline in sperm deoxyribonucleic acid integrity in patients evaluated for male infertility

SI Moskovtsev, J Willis, JBM Mullen - Fertility and sterility, 2006 - Elsevier
Age-related decline in sperm deoxyribonucleic acid integrity in patients evaluated for male
infertility - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …

Toxicants and human sperm chromatin integrity

G Delbes, BF Hales, B Robaire - MHR: Basic science of …, 2009 - academic.oup.com
The integrity of the paternal genome is essential as the spermatozoon can bring genetic
damage into the oocyte at fertilization and contribute to the development of abnormal …