The concept of the ischemic penumbra is an important one for both basic investigators of
cerebral ischemia and for clinicians who treat stroke patients. The ischemic penumbra has …

Active treatment of acute ischaemic stroke can only be successful as long as tissue in the
area of ischaemic compromise is still viable. Therefore, the identification of the area of …

Background and Purpose—Controlled multicenter studies have demonstrated the efficacy of
systemic recombinant tissue-type plasminogen activator (rtPA) treatment in selected cases …

Background and Purpose—Central benzodiazepine receptor ligands, such as [11C]
flumazenil (FMZ), are markers of neuronal integrity and therefore might be useful in the …

Objective mapping of irreversible tissue damage in the acute stage of ischaemic stroke
would be useful for prognosis and in assessing the efficacy of therapeutic manoeuvres in …

Background and Purpose—We sought to study the prognostic value of early 99mtechnetium–
ethyl-cysteinate-dimer single-photon emission CT (99mTc-ECD SPECT) for fatal ischemic …

Background and Purpose—Early ischemic changes on noncontrast CT in acute stroke
include both hypoattenuation and brain swelling, which may have different …

Objective: The purpose of this study was to compare the incidence of large hypoperfusion
(greater than two-thirds of MCA territory) on computed tomography (CT) perfusion maps …

The utility of diagnostic imaging during the critical first few hours after stroke onset has many
important applications. First and foremost, imaging technologies that can reliably detect and …

Background and Purpose—The presence of early x-ray hypoattenuation is an important
selection criterion for thrombolytic therapy. However, knowledge about the …