How to interpret and pursue an abnormal complete blood cell count in adults

A Tefferi, CA Hanson, DJ Inwards - Mayo Clinic Proceedings, 2005 - Elsevier
A complete blood cell count (CBC) is one of the most common laboratory tests in medicine.
For example, at our institution alone, approximately 1800 CBCs are ordered every day, and …

A systematic review on predisposition to lymphoid (B and T cell) neoplasias in patients with primary immunodeficiencies and immune dysregulatory disorders (inborn …

IB Riaz, W Faridi, MM Patnaik, RS Abraham - Frontiers in immunology, 2019 - frontiersin.org
Primary immunodeficiencies and immune dysregulatory disorders (PIDDs; now referred to
as inborn errors in immunity) are rare disorders with a prevalence of 41. 4 or 50.5 per …

Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency

B Grimbacher, A Hutloff, M Schlesier, E Glocker… - Nature …, 2003 - nature.com
No genetic defect is known to cause common variable immunodeficiency (CVID), a
heterogeneous human disorder leading to adult-onset panhypogammaglobulinemia. In a …

High-Throughput GoMiner, an'industrial-strength'integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of …

BR Zeeberg, H Qin, S Narasimhan, M Sunshine… - BMC …, 2005 - Springer
Abstract Background We previously developed GoMiner, an application that organizes lists
of'interesting'genes (for example, under-and overexpressed genes from a microarray …

B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency

GJ Driessen, MC Van Zelm… - Blood, The Journal …, 2011 - ashpublications.org
Common variable immunodeficiency disorder (CVID) is the most prevalent form of primary
idiopathic hypogammaglobulinemia. Identification of genetic defects in CVID is hampered by …

Gastrointestinal manifestations in patients with common variable immunodeficiency

A Khodadad, A Aghamohammadi, N Parvaneh… - Digestive diseases and …, 2007 - Springer
This study focuses on endoscopic and pathologic alterations of gastrointestinal (GI)
disorders of Iranian patients with common variable immunodeficiency (CVID). Nineteen of …

Common variable immunodeficiency: a review

M Di Renzo, AL Pasqui, A Auteri - Clinical and experimental medicine, 2004 - Springer
Common variable immunodeficiency (CVID) is the commonest symptomatic primary
antibody deficiency syndrome. The predominant manifestation is hypogammaglobulinemia …

Active vaccination in patients with common variable immunodeficiency (CVID)

S Goldacker, R Draeger, K Warnatz, D Huzly… - Clinical …, 2007 - Elsevier
Active vaccination of CVID patients with standard vaccines has rarely been studied in depth
although some patients have been shown to develop transient vaccine-specific immunity …

Infliximab treatment for severe granulomatous disease in common variable immunodeficiency: a case report and review of the literature

A Thatayatikom, S Thatayatikom, AJ White - Annals of Allergy, Asthma & …, 2005 - Elsevier
BACKGROUND: Granulomatous disease resembling sarcoidosis is a well-described
condition associated with common variable immunodeficiency (CVID). Its treatment remains …

Comparative in vitro immune stimulation analysis of primary human B cells and B cell lines

K Van Belle, J Herman, L Boon, M Waer… - Journal of …, 2016 - Wiley Online Library
B cell specific immunomodulatory drugs still remain an unmet medical need. Utilisation of
validated simplified in vitro models would allow readily obtaining new insights in the …