Sensory epithelia of the inner ear contain two major cell types: hair cells and supporting
cells. It has been clear for a long time that hair cells play critical roles in mechanoreception …

Vestibular sensation is essential for gaze stabilization, balance, and perception of gravity.
The vestibular receptors in mammals, Type I and Type II hair cells, are located in five small …

The adult mammalian inner ear lacks the capacity to divide or regenerate. Damage to inner
ear generally leads to permanent hearing loss in humans. Here, we present that …

Foxg1 plays important roles in regeneration of hair cell (HC) in the cochlea of neonatal
mouse. Here, we used Sox9-CreER to knock down Foxg1 in supporting cells (SCs) in the …

Hearing loss has become increasingly prevalent and causes considerable disability, thus
gravely burdening the global economy. Irreversible loss of hair cells is a main cause of …

Sensorineural hearing loss is caused by the loss of sensory hair cells and neurons of the
inner ear. Once lost, these cell types are not replaced. Two genes expressed in the …

Loss of sensory hair cells causes permanent hearing and balance deficits in humans and
other mammals, but for nonmammals such deficits are temporary. Nonmammals recover …

Hearing and balance deficits often affect humans and other mammals permanently, because
their ears stop producing hair cells within a few days after birth. But production occurs …

Hair cells regenerate throughout the lifetime of non-mammalian vertebrates, allowing these
animals to recover from hearing and balance deficits. Such regeneration does not occur …

The study of MYC has led to pivotal discoveries in cancer biology, induced pluripotency, and
transcriptional regulation. In this review, continuing advances in our understanding of the …