The cochlear implant (CI) is the first effective treatment for deafness and severe losses in
hearing. As such, the CI is now widely regarded as one of the great advances in modern …

Research in the genetics of hearing and deafness has evolved rapidly over the past years,
providing the molecular foundation for different aspects of the mechanism of hearing …

Recruitment of endogenous progenitors is critical during tissue repair. The inner ear utricle
requires mechanosensory hair cells (HCs) to detect linear acceleration. After damage, non …

Sensory hair cells of the inner ear are responsible for translating auditory or vestibular
stimuli into electrical energy that can be perceived by the nervous system. Although hair …

Death of mechanosensory cells in the inner ear results in two profound disabilities: hearing
loss and balance disorders. Although mammals lack the capacity to regenerate hair cells …

There is growing attention and effort focused on treating the root cause of sensorineural
hearing loss rather than managing associated secondary characteristic features. With recent …

The external location of the zebrafish lateral line makes it a powerful model for studying
mechanosensory hair cell regeneration. We have developed a chemical screen to identify …

Bilateral symmetric tissues must interpret axial references to maintain their global
architecture during growth or repair. The regeneration of hair cells in the zebrafish lateral …

Balance disequilibrium is a significant contributor to falls in the elderly. The most common
cause of balance dysfunction is loss of sensory cells from the vestibular sensory epithelia of …

Human vestibular sensory epithelia in explant culture were incubated in gentamicin to
ablate hair cells. Subsequent transduction of supporting cells with ATOH1 using an Ad-2 …