Resistance to EGF-R (erbB-1) and VEGF-R modulating agents

WCM Dempke, V Heinemann - European journal of cancer, 2009 - Elsevier
In an effort to improve the survival of cancer patients, new therapeutic approaches focusing
on the molecular mechanisms that mediate tumour cell growth or survival have gained much …

Correlation of F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value and EGFR mutations in advanced lung adenocarcinoma

CT Huang, RF Yen, MF Cheng, YC Hsu, PF Wei… - Medical Oncology, 2010 - Springer
Objective Epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma are
involved in the tumorigenesis and regulation of cell metabolism via Akt signaling. F-18 …

[HTML][HTML] Gefitinib in the treatment of nonsmall cell lung cancer with activating epidermal growth factor receptor mutation

F Nurwidya, F Takahashi… - Journal of natural science …, 2016 - ncbi.nlm.nih.gov
Lung cancer is still the main cause of cancer-related deaths worldwide, with most patients
present with advanced disease and poor long-term prognosis. The aim of lung cancer …

American society of clinical oncology clinical practice guideline update on chemotherapy for stage IV non–small-cell lung cancer

CG Azzoli, G Giaccone, S Temin - Journal of oncology practice, 2010 - ascopubs.org
American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy
for Stage IV Non–Small-Cell Lung Cancer | JCO Oncology Practice Skip to main content …

Targeting receptor tyrosine kinase signalling in small cell lung cancer (SCLC): what have we learned so far?

B Fischer, M Marinov, A Arcaro - Cancer treatment reviews, 2007 - Elsevier
Small cell lung cancer (SCLC) is an aggressive form of lung cancer, which represents 13%
of all cases and is strongly associated with cigarette smoking. The survival of SCLC patients …

Healthcare costs in patients with advanced non-small cell lung cancer and disease progression during targeted therapy: a real-world observational study

KE Skinner, AW Fernandes, MS Walker… - Journal of medical …, 2018 - Taylor & Francis
Aims: To assess healthcare costs during treatment with epidermal growth factor receptor
(EGFR) tyrosine kinase inhibitors (TKIs) and following disease progression in patients with …

The “Lazarus Response” in treatment-naïve, poor performance status patients with non–small-cell lung cancer and epidermal growth factor receptor mutation

CJ Langer - Journal of Clinical Oncology, 2009 - ascopubs.org
In a series of more than 500 non–small-cell lung cancer (NSCLC) patients evaluated by
Cella and colleagues in quality of life studies, the prevalence of poor performance status …

Incidence and risk of xerosis with targeted anticancer therapies

J Valentine, VR Belum, J Duran, K Ciccolini… - Journal of the American …, 2015 - Elsevier
Background Many targeted therapies used in the treatment of cancer can lead to the
development of xerosis, but the incidence and relative risk of xerosis have not been …

EGFR-targeted therapies in lung cancer: predictors of response and toxicity

RS Heist, D Christiani - Pharmacogenomics, 2009 - Taylor & Francis
The EGFR pathway has emerged as a key target in non-small-cell lung cancer. EGF
receptor (EGFR) inhibition in non-small-cell lung cancer is achieved via small molecular …

Current status of biomarkers in head and neck cancer

SS Chang, J Califano - Journal of surgical oncology, 2008 - Wiley Online Library
As our understanding of HNSCC increases so has biomarker development. HPV16
integration is a significant marker of favorable prognosis and response to therapy for …