Humoral immune responses at mucosal surfaces have historically focused on IgA. Growing
evidence highlights the complexity of IgA-inducing pathways and the functional impact of IgA …

Patients with a diverse spectrum of rare genetic disorders can present with inflammatory
bowel disease (monogenic IBD). Patients with these disorders often develop symptoms …

Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, has
multifactorial aetiology with complex interactions between genetic and environmental …

Mucosal surfaces are colonized by large communities of commensal bacteria and represent
the primary site of entry for pathogenic agents. To prevent microbial intrusion, mucosal B …

Common variable immune deficiency (CVID) is the most frequent symptomatic primary
immune deficiency in adults. The standard of care is intravenous immunoglobulin (IVIG) or …

BACKGROUND: Clinical immunology has traditionally relied on accurate phenotyping of the
patient's immune dysfunction for the identification of a candidate gene or genes for …

Gastrointestinal disorders such as chronic or acute diarrhea, malabsorption, abdominal
pain, and inflammatory bowel diseases can indicate immune deficiency. The gastrointestinal …

Common variable immunodeficiency disorders (CVIDs) are the most frequent symptomatic
primary immune deficiency condition in adults. The genetic basis for the condition is not …

Common variable immune deficiency (CVID) and chronic granulomatous disease (CGD) are
two of the well-characterized primary immune deficiencies with distinct pathologic defects …

Common variable immune deficiency (CVID) is the commonest symptomatic primary
immunodeficiency and represents a heterogenous collection of disorders resulting mostly in …