A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development
The allostatic load (AL) model represents an interdisciplinary approach to comprehensively
conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle …
conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle …
Role of central dopamine in pain and analgesia
PB Wood - Expert review of neurotherapeutics, 2008 - Taylor & Francis
Recent insights have demonstrated a central role for dopaminergic neurotransmission in
modulating pain perception and natural analgesia within supraspinal regions, including the …
modulating pain perception and natural analgesia within supraspinal regions, including the …
[PDF][PDF] Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's disease
DJ Vidyadhara, M Somayaji, N Wade, B Yücel, H Zhao… - Cell reports, 2023 - cell.com
Auxilin participates in the uncoating of clathrin-coated vesicles (CCVs), thereby facilitating
synaptic vesicle (SV) regeneration at presynaptic sites. Auxilin (DNAJC6/PARK19) loss-of …
synaptic vesicle (SV) regeneration at presynaptic sites. Auxilin (DNAJC6/PARK19) loss-of …
Variation in dopamine genes influences responsivity of the human reward system
JC Dreher, P Kohn, B Kolachana… - Proceedings of the …, 2009 - National Acad Sciences
In humans, dopamine neurotransmission is influenced by functional polymorphisms in the
dopamine transporter (DAT 1) and catechol-O-methyltransferase (COMT) genes. Here, we …
dopamine transporter (DAT 1) and catechol-O-methyltransferase (COMT) genes. Here, we …
Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care
Extensive neuropathological studies have established a compelling link between
abnormalities in structure and function of subcortical monoaminergic (MA-ergic) systems …
abnormalities in structure and function of subcortical monoaminergic (MA-ergic) systems …
[HTML][HTML] Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome
Identifying patients who are potential placebo responders has major implications for clinical
practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in …
practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in …
The 22q11. 2 deletion syndrome as a window into complex neuropsychiatric disorders over the lifespan
RK Jonas, CA Montojo, CE Bearden - Biological psychiatry, 2014 - Elsevier
Evidence is rapidly accumulating that rare, recurrent copy number variants represent large
effect risk factors for neuropsychiatric disorders. 22q11. 2 deletion syndrome (22q11DS) …
effect risk factors for neuropsychiatric disorders. 22q11. 2 deletion syndrome (22q11DS) …
Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice
The COMT (catechol-O-methyltransferase) gene has been linked to a spectrum of human
phenotypes, including cognition, anxiety, pain sensitivity and psychosis. Doubts about its …
phenotypes, including cognition, anxiety, pain sensitivity and psychosis. Doubts about its …
[HTML][HTML] Coming of age in the frontal cortex: The role of puberty in cortical maturation
Across species, adolescence is a period of growing independence that is associated with
the maturation of cognitive, social, and affective processing. Reorganization of neural …
the maturation of cognitive, social, and affective processing. Reorganization of neural …
Genetic approaches to addiction: genes and alcohol
F Ducci, D Goldman - Addiction, 2008 - Wiley Online Library
Aims Alcoholism is a chronic relapsing disorder with an enormous societal impact.
Understanding the genetic basis of alcoholism is crucial to characterize individuals' risk and …
Understanding the genetic basis of alcoholism is crucial to characterize individuals' risk and …