Across species, adolescence is a period of growing independence that is associated with
the maturation of cognitive, social, and affective processing. Reorganization of neural …

J. Neurochem.(2010) 114, 1745–1755. Abstract Catechol‐O‐methyltransferase (COMT)
plays an active role in the metabolism of dopamine (DA) in the prefrontal cortex (PFC) …

Mutant mouse models related to schizophrenia have been based primarily on the
pathophysiology of schizophrenia, the known effects of antipsychotic drugs, and candidate …

Various genes are known to modulate the delicate balance of dopamine in prefrontal cortex
and influence cortical information processing. Catechol-O-methyltransferase (COMT) on …

Cognitive dysfunction in schizophrenia is an important target for novel therapies. Effectively
measuring the cognitive effects of compounds in clinical trials of schizophrenia could be a …

Studies in adolescents and adults have demonstrated that polymorphisms in putative
psychiatric risk genes are associated with differences in brain structure, but cannot address …

AKT1-dependent molecular pathways control diverse aspects of cellular development and
adaptation, including interactions with neuronal dopaminergic signaling. If AKT1 has an …

Hofmeister effects have often been ignored in living organisms, although they affect the
activity and functions of biological molecules. Herein, amperometry has been applied to …

Neurodevelopmental disorders (NDs) encompass a spectrum of neuropsychiatric
manifestations. Chromosomal regions 1q21. 1, 3q29, 15q11. 2, 15q13. 3, 16p11. 2, 16p13. 1 …

Similar to dopamine (DA), cannabinoids strongly influence prefrontal cortical functions, such
as working memory, emotional learning, and sensory perception. Although endogenous …