Stem and progenitor cell alterations in myelodysplastic syndromes
Recent studies have demonstrated that myelodysplastic syndromes (MDSs) arise from a
small population of disease-initiating hematopoietic stem cells (HSCs) that persist and …
small population of disease-initiating hematopoietic stem cells (HSCs) that persist and …
Fluorescence in situ hybridization (FISH): an increasingly demanded tool for biomarker research and personalized medicine
L Hu, K Ru, L Zhang, Y Huang, X Zhu, H Liu… - Biomarker …, 2014 - Springer
Extensive studies of the genetic aberrations related to human diseases conducted over the
last two decades have identified recurrent genomic abnormalities as potential driving factors …
last two decades have identified recurrent genomic abnormalities as potential driving factors …
Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes—proposal from the International/European …
A Porwit, AA Van De Loosdrecht, P Bettelheim… - Leukemia, 2014 - nature.com
Definite progress has been made in the exploration of myelodysplastic syndromes (MDS) by
flow cytometry (FCM) since the publication of the World Health Organization 2008 …
flow cytometry (FCM) since the publication of the World Health Organization 2008 …
DNA methylation events as markers for diagnosis and management of acute myeloid leukemia and myelodysplastic syndrome
GM Dexheimer, J Alves, L Reckziegel… - Disease …, 2017 - Wiley Online Library
During the onset and progression of hematological malignancies, many changes occur in
cellular epigenome, such as hypo‐or hypermethylation of CpG islands in promoter regions …
cellular epigenome, such as hypo‐or hypermethylation of CpG islands in promoter regions …
The evolving field of prognostication and risk stratification in MDS: Recent developments and future directions
The clinical course of patients with myelodysplastic syndromes (MDS) is characterized by
wide variability reflecting the underlying genetic and biological heterogeneity of the disease …
wide variability reflecting the underlying genetic and biological heterogeneity of the disease …
Epigenetics in focus: pathogenesis of myelodysplastic syndromes and the role of hypomethylating agents
Dysregulation of cellular epigenetic machinery is considered a major pathogenetic
determinant in many malignancies, including myelodysplastic syndromes (MDS). The …
determinant in many malignancies, including myelodysplastic syndromes (MDS). The …
There's risk, and then there's risk: the latest clinical prognostic risk stratification models in myelodysplastic syndromes
AM Zeidan, RS Komrokji - Current hematologic malignancy reports, 2013 - Springer
Myelodysplastic syndromes (MDS) include a diverse group of clonal hematopoietic
disorders characterized by progressive cytopenias and propensity for leukemic progression …
disorders characterized by progressive cytopenias and propensity for leukemic progression …
Genetic variants involved in oxidative stress, base excision repair, DNA methylation, and folate metabolism pathways influence myeloid neoplasias susceptibility and …
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) share common
features: elevated oxidative stress, DNA repair deficiency, and aberrant DNA methylation …
features: elevated oxidative stress, DNA repair deficiency, and aberrant DNA methylation …
Hypomethylating agents (HMA) treatment for myelodysplastic syndromes: alternatives in the frontline and relapse settings
N Uy, A Singh, SD Gore, T Prebet - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Hypomethylating agents (HMA) have played a pivotal role for treating
myelodysplastic syndromes (MDS) over the past decade, inducing sustained hematological …
myelodysplastic syndromes (MDS) over the past decade, inducing sustained hematological …
Cytogenetic as an important tool for diagnosis and prognosis for patients with hypocellular primary myelodysplastic syndrome
D Corrêa de Souza… - BioMed Research …, 2014 - Wiley Online Library
We analyzed cytogenetically 105 patients with hypocellular primary MDS and their clinical
implications. The main chromosomal abnormalities found were del (5q)/− 5, del (6q)/+ 6, del …
implications. The main chromosomal abnormalities found were del (5q)/− 5, del (6q)/+ 6, del …