Nicotine metabolism pathway in bacteria: mechanism, modification, and application

Z Zhang, X Mei, Z He, X Xie, Y Yang, C Mei… - Applied Microbiology …, 2022 - Springer
Nicotine is a harmful pollutant mainly from the waste of tobacco factories. It is necessary to
remove nicotine via high efficient strategies such as bioremediation. So far, an increasing …

Phytochemicals derived from Nicotiana tabacum L. plant contribute to pharmaceutical development

W Zhang, X Pan, J Fu, W Cheng, H Lin… - Frontiers in …, 2024 - frontiersin.org
The Nicotiana tabacum L. plant, a medicinal resource, holds significant potential for
benefiting human health, as evidenced by its use in Native American and ancient Chinese …

Anxiolytic, Promnesic, Anti-Acetylcholinesterase and Antioxidant Effects of Cotinine and 6-Hydroxy-L-Nicotine in Scopolamine-Induced Zebrafish (Danio rerio) Model …

RS Boiangiu, M Mihasan, DL Gorgan, BA Stache… - Antioxidants, 2021 - mdpi.com
Cotinine (COT) and 6-hydroxy-L-nicotine (6HLN) are two nicotinic derivatives that possess
cognitive-improving abilities and antioxidant properties in different rodent models of …

Ameliorative effects of Matricaria chamomilla L. hydroalcoholic extract on scopolamine-induced memory impairment in rats: A behavioral and molecular study

R Ionita, PA Postu, M Mihasan, DL Gorgan… - Phytomedicine, 2018 - Elsevier
Background Matricaria chamomilla L. is a medicinal herb traditionally used as the anti-
inflammatory, antimicrobial, antiviral, anxiolytic and antidepressant agent. Nevertheless …

Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway

MA Dezfouli, M Zahmatkesh, M Farahmandfar… - Physiology & …, 2019 - Elsevier
Melatonin has a potential therapeutic value in Alzheimer's disease (AD), a disease that is
associated with a dramatic decline in memory and cognitive abilities. The aggregation of the …

Nicotine prevents oxidative stress-induced hippocampal neuronal injury through α7-nAChR/Erk1/2 signaling pathway

Y Dong, W Bi, K Zheng, E Zhu, S Wang… - Frontiers in Molecular …, 2020 - frontiersin.org
Oxidative stress-induced neuronal damage has been implicated to play a dominant role in
neurodegenerative disorders, such as Alzheimer's disease (AD). Nicotine, a principal …

Scaffold searching of FDA and EMA-approved drugs Identifies lead candidates for drug repurposing in Alzheimer's Disease

S Shityakov, EV Skorb, CY Förster… - Frontiers in Chemistry, 2021 - frontiersin.org
Clinical trials of novel therapeutics for Alzheimer's Disease (AD) have consumed a
significant amount of time and resources with largely negative results. Repurposing drugs …

Cotinine and 6-Hydroxy-L-Nicotine Reverses Memory Deficits and Reduces Oxidative Stress in Aβ25-35-Induced Rat Model of Alzheimer's Disease

RS Boiangiu, M Mihasan, DL Gorgan, BA Stache… - Antioxidants, 2020 - mdpi.com
The nicotinic derivatives, cotinine (COT), and 6-hydroxy-L-nicotine (6HLN), showed
promising cognitive-improving effects without exhibiting the nicotine's side-effects. Here, we …

Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine

R Ionita, PA Postu, GJ Beppe, M Mihasan… - Behavioral and Brain …, 2017 - Springer
Background Plants of the genus Markhamia have been traditionally used by different tribes
in various parts of West African countries, including Cameroun. Markhamia tomentosa …

Protective effects of Mentha spicata against nicotine-induced toxicity in liver and erythrocytes of Wistar rats

A Ben Saad, I Rjeibi, H Alimi, S Ncib… - Applied Physiology …, 2018 - cdnsciencepub.com
The aim of this study was to investigate the protective effect of Mentha spicata
supplementation against nicotine-induced oxidative damage in the liver and erythrocytes of …