The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy
H Wang, X Zhou, C Li, S Yan, C Feng, J He… - Journal of hematology & …, 2022 - Springer
Pediatric cancers are the driving cause of death for children and adolescents. Due to safety
requirements and considerations, treatment strategies and drugs for pediatric cancers have …
requirements and considerations, treatment strategies and drugs for pediatric cancers have …
Insights into the role of LncRNAs and miRNAs in glioma progression and their potential as novel therapeutic targets
Simple Summary Recent research has revealed the involvement of long non-coding RNAs
(lncRNAs) and micro RNAs (miRNAs) in glioma development and advancement, suggesting …
(lncRNAs) and micro RNAs (miRNAs) in glioma development and advancement, suggesting …
A novel MYCN-YTHDF1 cascade contributes to retinoblastoma tumor growth by eliciting m6A -dependent activation of multiple oncogenes
Y Luo, M He, J Yang, F Zhang, J Chen, X Wen… - Science China Life …, 2023 - Springer
Retinoblastoma, the most prevalent primary intraocular tumor in children, leads to vision
impairment, disability and even death. In addition to RB1 inactivation, MYCN activation has …
impairment, disability and even death. In addition to RB1 inactivation, MYCN activation has …
Amentoflavone and methyl hesperidin, novel lead molecules targeting epitranscriptomic modulator in acute myeloid leukemia: In silico drug screening and molecular …
S Manna, P Samal, R Basak, A Mitra, AK Roy… - Journal of Molecular …, 2023 - Springer
Introduction M6A modification in transcriptome is critical in regulating different cellular
processes, including cancer. In human beings, METTL3 is the major m6A writer that works in …
processes, including cancer. In human beings, METTL3 is the major m6A writer that works in …
N6-methyladenosine methylation regulator FTO promotes oxidative stress and induces cell apoptosis in ovarian cancer
J Wu, X Wang, X Li - Epigenomics, 2022 - Taylor & Francis
Aims: This study aimed to reveal the possible molecular mechanism of n6-methyladenosine
(m6A) methylation regulator FTO in the biological activities of ovarian cancer (OC) based on …
(m6A) methylation regulator FTO in the biological activities of ovarian cancer (OC) based on …
METTL3 achieves lipopolysaccharide-induced myocardial injury via m6A-dependent stabilization of Myh3 mRNA
C Gong, J Wu, H Li, C Luo, G Ji, X Guan, J Liu… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Septic cardiomyopathy (SCM) was an important pathological component of severe sepsis
and septic shock. N6-methyladenosine (m 6 A) modification was a common RNA …
and septic shock. N6-methyladenosine (m 6 A) modification was a common RNA …
XNA probe and CRISPR/Cas12a-powered flexible fluorescent and electrochemical dual-mode biosensor for sensitive detection of m6A site-specific RNA modification
Q Pu, Y Ye, J Hu, C Xie, X Zhou, H Yu, F Liao, S Jiang… - Talanta, 2023 - Elsevier
Abstract N6-methyladenosine (m6A) in RNAs is closely related to various biological
progresses, but the specific regulatory mechanisms are still unclear. The existing m6A single …
progresses, but the specific regulatory mechanisms are still unclear. The existing m6A single …
N6‐methyladenosine‐modified HOTAIRM1 promotes vasculogenic mimicry formation in glioma
Z Wu, Y Lin, N Wei - Cancer Science, 2023 - Wiley Online Library
Vasculogenic mimicry (VM) has been reported to accelerate angiogenesis in malignant
tumors, yet the mechanism underlying VM has not been fully elucidated. N6 …
tumors, yet the mechanism underlying VM has not been fully elucidated. N6 …
RNA m6A methylation regulators in liver cancer
Q Xu, N Ren, L Ren, Y Yang, J Pan, H Shang - Cancer Cell International, 2024 - Springer
Liver cancer is one of the most common cancers in the world and a primary cause of cancer-
related death. In recent years, despite the great development of diagnostic methods and …
related death. In recent years, despite the great development of diagnostic methods and …
The effects of epigenetic modifications on bone remodeling in age-related osteoporosis
Purpose: As the population ages, there is an increased risk of fracture and morbidity
diseases associated with aging, such as age-related osteoporosis and other bone diseases …
diseases associated with aging, such as age-related osteoporosis and other bone diseases …