Emerging functions of the EGFR in cancer
S Sigismund, D Avanzato, L Lanzetti - Molecular oncology, 2018 - Wiley Online Library
The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …
Small-molecule probes from bench to bedside: advancing molecular analysis of drug–target interactions toward precision medicine
Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …
small-molecule probes. These molecular tools have been widely applied for interrogating …
A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer
Epithelial growth factor receptor (EGFR) is a cell surface transmembrane receptor that
mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell …
mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell …
Extracellular vesicle drug occupancy enables real-time monitoring of targeted cancer therapy
Current technologies to measure drug–target interactions require complex processing and
invasive tissue biopsies, limiting their clinical utility for cancer treatment monitoring. Here we …
invasive tissue biopsies, limiting their clinical utility for cancer treatment monitoring. Here we …
TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
High expression or aberrant activation of epidermal growth factor receptor (EGFR) is related
to tumor progression and therapy resistance across cancer types, including non-small cell …
to tumor progression and therapy resistance across cancer types, including non-small cell …
EGFR-mediated autophagy in tumourigenesis and therapeutic resistance
M Wu, P Zhang - Cancer letters, 2020 - Elsevier
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that links
extracellular signals to the control of cell survival, growth, proliferation and differentiation …
extracellular signals to the control of cell survival, growth, proliferation and differentiation …
[HTML][HTML] The calcium binding protein S100A11 and its roles in diseases
L Zhang, T Zhu, H Miao, B Liang - Frontiers in cell and developmental …, 2021 - frontiersin.org
The calcium binding protein S100 family in humans contains 21 known members, with each
possessing a molecular weight between 10 and 14 kDa. These proteins are characterized …
possessing a molecular weight between 10 and 14 kDa. These proteins are characterized …
FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth
M Niu, J Xu, Y Liu, Y Li, T He, L Ding, Y He, Y Yi… - Nature …, 2021 - nature.com
Abnormal activation of epidermal growth factor receptor (EGFR) drives non-small cell lung
cancer (NSCLC) development. EGFR mutations-mediated resistance to tyrosine-kinase …
cancer (NSCLC) development. EGFR mutations-mediated resistance to tyrosine-kinase …
[HTML][HTML] Binding features and functions of ATG3
Autophagy is an evolutionarily conserved catabolic process that is essential for maintaining
cellular, tissue, and organismal homeostasis. Autophagy-related (ATG) genes are …
cellular, tissue, and organismal homeostasis. Autophagy-related (ATG) genes are …
Targeting autophagy for overcoming resistance to anti-EGFR treatments
Epidermal growth factor receptor (EGFR) plays critical roles in cell proliferation,
tumorigenesis, and anti-cancer drug resistance. Overexpression and somatic mutations of …
tumorigenesis, and anti-cancer drug resistance. Overexpression and somatic mutations of …