Overexpression of EGFR drives glioblastomas (GBM) cell invasion but these tumours remain
resistant to EGFR-targeted therapies such as tyrosine kinase inhibitors (TKIs). Endocytosis …

Antibody combinations targeting cell surface receptors are a new modality of cancer therapy.
The trafficking and signalling mechanisms regulated by such therapeutics are not fully …

JMJD8 is a JmjC domain-containing protein that has not been widely examined, despite its
potential role in malignant tumor development. The underlying biological functions and …

A transcription factor p53 is activated upon cellular exposure to endogenous and exogenous
stresses, triggering either homeostatic correction or cell death. Depending on the stress …

Interactions between cells and their environment influence key physiologic processes such
as their propensity to migrate. However, directed migration controlled by extrinsically applied …

Ligand‐independent epidermal growth factor receptor (EGFR) endocytosis is inducible by a
variety of stress conditions converging upon p38 kinase. A less known pathway involves …

Targeted therapy has been recently highlighted due to the reduction of side effects and
improvement in overall efficacy and survival from different types of cancers. Considering the …

Simple Summary The EGFR is a tyrosine kinase receptor that responds to different stresses
such as UV irradiation, hypoxia and drug treatment by internalizing into endosomal …

Receptor degradation terminates signaling by activated receptor tyrosine kinases.
Degradation of EGFR occurs in lysosomes and requires the switching of RAB5 for RAB7 on …

Lower-extremity diabetic ulcers are responsible for 80% of annual worldwide nontraumatic
amputations. Epidermal growth factor (EGF) reduction is one of the molecular pillars of …