Mammalian cell transfection: the present and the future

TK Kim, JH Eberwine - Analytical and bioanalytical chemistry, 2010 - Springer
Transfection is a powerful analytical tool enabling study of the function of genes and gene
products in cells. The transfection methods are broadly classified into three groups; …

Functional nucleic acid sensors

J Liu, Z Cao, Y Lu - Chemical reviews, 2009 - ACS Publications
Sensors are devices that respond to physical or chemical stimuli and produce detectable
signals. 1r4 They are a critical extension of human perception of the world in many aspects …

RNA interference: biology, mechanism, and applications

N Agrawal, PVN Dasaradhi, A Mohmmed… - Microbiology and …, 2003 - Am Soc Microbiol
Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of
silencing gene expression in a range of organisms. The silencing of a gene is a …

Catalytic nucleic acids: biochemistry, chemical biology, biosensors, and nanotechnology

L Ma, J Liu - Iscience, 2020 - cell.com
Since the initial discovery of ribozymes in the early 1980s, catalytic nucleic acids have been
used in different areas. Compared with protein enzymes, catalytic nucleic acids are …

Engineered nucleic acids encoding a modified erythropoietin and their expression

JP Schrum, NB Afeyan, GJ Sieczkiewicz… - US Patent …, 2014 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Antisense technologies: improvement through novel chemical modifications

J Kurreck - European journal of biochemistry, 2003 - Wiley Online Library
Antisense agents are valuable tools to inhibit the expression of a target gene in a sequence‐
specific manner, and may be used for functional genomics, target validation and therapeutic …

Killing the messenger: short RNAs that silence gene expression

DM Dykxhoorn, CD Novina, PA Sharp - Nature reviews Molecular cell …, 2003 - nature.com
Short interfering RNAs can be used to silence gene expression in a sequence-specific
manner in a process that is known as RNA interference. The application of RNA interference …

[图书][B] Introduction to nanoscience and nanotechnology

GL Hornyak, HF Tibbals, J Dutta, JJ Moore - 2008 - api.taylorfrancis.com
The maturation of nanotechnology has revealed it to be a unique and distinct discipline
rather than a specialization within a larger field. Its textbook cannot afford to be a chemistry …

Functional aptamers and aptazymes in biotechnology, diagnostics, and therapy

M Famulok, JS Hartig, G Mayer - Chemical reviews, 2007 - ACS Publications
Aptamers are single-stranded nucleic acid molecules that possess properties comparable to
those of protein monoclonal antibodies, and thus are clear alternatives to long established …

siRNAs: applications in functional genomics and potential as therapeutics

Y Dorsett, T Tuschl - Nature reviews Drug discovery, 2004 - nature.com
Molecules that can specifically silence gene expression are powerful research tools. Much
effort has been put into the development of such molecules and has resulted in the creation …