Synthesis of complex carbohydrates and glycoconjugates: enzyme-based and programmable one-pot strategies

KM Koeller, CH Wong - Chemical Reviews, 2000 - ACS Publications
Identifying the functional roles of carbohydrates in biological systems has been an area of
intense study in recent years. Although carbohydrates were once viewed only as inert …

Recent advances in the chemoenzymatic synthesis of carbohydrates and carbohydrate mimetics

HJM Gijsen, L Qiao, W Fitz, CH Wong - Chemical reviews, 1996 - ACS Publications
The aldol condensation has been an effective method in organic synthesis for the formation
of carboncarbon bonds. 1 Much effort has been directed toward making these reactions …

Enzymes in organic synthesis: Application to the problems of carbohydrate recognition (part 2)

CH Wong, RL Halcomb, Y Ichikawa… - … International Edition in …, 1995 - Wiley Online Library
Recognition of carbohydrates by proteins and nucleic acids is highly specific, but the
dissociation constants are relatively high (generally in the mm to high μm range) because of …

Two-State Reactivity in the Rebound Step of Alkane Hydroxylation by Cytochrome P-450: Origins of Free Radicals with Finite Lifetimes This research was sponsored …

N Harris, S Cohen, M Filatov… - … (International ed. in …, 2000 - pubmed.ncbi.nlm.nih.gov
Two-State Reactivity in the Rebound Step of Alkane Hydroxylation by Cytochrome P-450:
Origins of Free Radicals with Finite Lifetimes This research was sponsored by the Israeli …

Applications of enzymes in synthetic carbohydrate chemistry

J Thiem - FEMS microbiology reviews, 1995 - academic.oup.com
By photosynthesis 200 billion tons of glucose are formed per annum most of which remains
in the sugar state. Thus, the well-known properties of saccharides as the basis for structural …

Glycosyltransferases in the synthesis of oligosaccharide analogs

MM Palcic, O Hindsgaul - Trends in Glycoscience and …, 1996 - jstage.jst.go.jp
抄録 この総説では糖転移酵素によるオリゴ糖類似体の合成について概観する. 特に,
化学修飾された糖ヌクレオチド供与体, あるいは化学修飾された糖受容体を基質として用いたものに …

In vitro glycosylation of proteins: an enzymatic approach

I Meynial-Salles, D Combes - Journal of biotechnology, 1996 - Elsevier
The glycosylation pathway is the most important post-translational modification of a protein
and is moreover a highly specific process. The majority of proteins of pharmaceutical interest …

Enzyme in der organischen Synthese: das Problem der molekularen Erkennung von Kohlenhydraten (Teil 2)

CH Wong, RL Halcomb, Y Ichikawa… - Angewandte …, 1995 - Wiley Online Library
Abstract Die molekulare Erkennung von Kohlenhydraten durch Proteine und Nucleinsäuren
ist hochspezifisch, obwohl die Dissoziationskonstanten aufgrund der bei Kohlenhydraten …

Novel features of acceptor recognition by β-(1→ 4)-galactosyltransferase

Y Kajihara, H Kodama, T Endo, H Hashimoto - Carbohydrate research, 1998 - Elsevier
In order to understand how β-(1→ 4)-galactosyltransferase recognizes its glycosyl acceptor,
substrate specificities were investigated using synthetic 2-acetamido-2-deoxy-d …

Chemical transformations employing glycosyltransferases

U Gambert, J Thiem - Glycoscience Synthesis of Oligosaccharides and …, 2008 - Springer
Abstract Early on, Emil Fischer proposed the use and technological application of enzymes
in natural product chemistry, in particular in peptide and carbohydrate synthesis. After …