[HTML][HTML] The evolution of commercial drug delivery technologies

AM Vargason, AC Anselmo, S Mitragotri - Nature biomedical …, 2021 - nature.com
Drug delivery technologies have enabled the development of many pharmaceutical
products that improve patient health by enhancing the delivery of a therapeutic to its target …

[HTML][HTML] Advances in oral drug delivery

MS Alqahtani, M Kazi, MA Alsenaidy… - Frontiers in …, 2021 - frontiersin.org
The oral route is the most common route for drug administration. It is the most preferred
route, due to its advantages, such as non-invasiveness, patient compliance and …

[HTML][HTML] Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics

DV Bhalani, B Nutan, A Kumar, AK Singh Chandel - Biomedicines, 2022 - mdpi.com
The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

Late-stage functionalization for improving drug-like molecular properties

NJ Castellino, AP Montgomery, JJ Danon… - Chemical …, 2023 - ACS Publications
The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …

[HTML][HTML] Advances in drug delivery systems, challenges and future directions

TC Ezike, US Okpala, UL Onoja, CP Nwike, EC Ezeako… - Heliyon, 2023 - cell.com
Advances in molecular pharmacology and an improved understanding of the mechanism of
most diseases have created the need to specifically target the cells involved in the initiation …

Therapeutics data commons: Machine learning datasets and tasks for drug discovery and development

K Huang, T Fu, W Gao, Y Zhao, Y Roohani… - arXiv preprint arXiv …, 2021 - arxiv.org
Therapeutics machine learning is an emerging field with incredible opportunities for
innovatiaon and impact. However, advancement in this field requires formulation of …

Overview of nanoparticulate strategies for solubility enhancement of poorly soluble drugs

KU Khan, MU Minhas, SF Badshah, M Suhail, A Ahmad… - Life Sciences, 2022 - Elsevier
Poor aqueous solubility and poor bioavailability are major issues with many pharmaceutical
industries. By some estimation, 70–90% drug candidates in development stage while up-to …

[HTML][HTML] A review of techniques for the application of bioactive coatings on metal-based implants to achieve controlled release of active ingredients

KA Kravanja, M Finšgar - Materials & Design, 2022 - Elsevier
Metallic implants have the disadvantage of being insufficiently biologically active despite
their good mechanical properties and general affordability. Therefore, their bone growth at …

Structural analysis of molecular materials using the pair distribution function

MW Terban, SJL Billinge - Chemical Reviews, 2021 - ACS Publications
This is a review of atomic pair distribution function (PDF) analysis as applied to the study of
molecular materials. The PDF method is a powerful approach to study short-and …

[HTML][HTML] SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

A Daina, O Michielin, V Zoete - Scientific reports, 2017 - nature.com
To be effective as a drug, a potent molecule must reach its target in the body in sufficient
concentration, and stay there in a bioactive form long enough for the expected biologic …