The ideal drug delivery system has a bioavailability comparable to parenteral dosage forms
but is as convenient and easy to use for the patient as oral solid dosage forms. In recent …

An outstanding challenge in deep learning in chemistry is its lack of interpretability. The
inability of explaining why a neural network makes a prediction is a major barrier to …

Poor water solubility of many drugs has emerged as one of the major challenges in the
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …

Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug
administration routes. Oral and injectable drug administration are the most common routes …

Spray drying is increasingly becoming recognized as an efficient drying and formulation
technique for pharmaceutical and biopharmaceutical processing. It offers significant …

Oral administration provides a simple and non-invasive approach for drug delivery.
However, due to poor absorption and swift enzymatic degradation in the gastrointestinal …

Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug
compounds that limits in vivo bioavailability owing to their low dissolution rate in the …

Drugs with low water solubility are predisposed to poor and variable oral bioavailability and,
therefore, to variability in clinical response, that might be overcome through an appropriate …

Many lead compounds fail to reach clinical trials despite being potent because of low
bioavailability attributed to their insufficient solubility making solubility a primary and crucial …

Although the oral route is the most convenient route for drug administration, there are a
number of circumstances where this is not possible from either a clinical or pharmaceutical …