Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

Nanosponges are nanosized drug carriers with a three-dimensional structure created by
crosslinking polymers. They have the advantage of being able to hold a wide range of drugs …

New approaches in pharmaceutical chemistry have resulted in more complex drug
molecules in the quest to achieve higher affinity to their targets. However, these 'highly …

Hydrophobic ion pairing has emerged as a method to modulate the solubility of charged
hydrophilic molecules ranging in class from small molecules to large enzymes. Charged …

During the past few decades, supercritical fluid (SCF) has emerged as an effective
alternative for many traditional pharmaceutical manufacturing processes. Operating active …

In the design of greener chemicals, deep eutectic solvents (DESs) are considered as one of
the most versatile alternative media with widespread applications. DESs have the …

Tablets are the most widely utilized solid oral dosage forms because of the advantages of
self-administration, stability, ease of handling, transportation, and good patient compliance …

Platinum drugs have been a mainstay of cancer chemotherapy since the introduction of
cisplatin in the 1970s. Since then, carboplatin and oxaliplatin have been approved world …

Nanogels/microgels are swollen cross-linked polymer networks with tunable
physicochemical properties and are commonly employed for the effective delivery of …

A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …