Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and …

AH Hasan, S Murugesan, SI Amran, S Chander… - Bioorganic …, 2022 - Elsevier
A series of around eight novel chalcone based coumarin derivatives (23a-h) was designed,
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …

Application of montmorillonite in bentonite as a pharmaceutical excipient in drug delivery systems

JH Park, HJ Shin, MH Kim, JS Kim, N Kang… - Journal of …, 2016 - Springer
Montmorillonite is a multifunctional clay mineral and a major component of bentonite.
Montmorillonite has been used in various industrial and pharmaceutical fields due to its …

Current trends on solid dispersions: past, present, and future

R Malkawi, WI Malkawi, Y Al-Mahmoud… - Advances in …, 2022 - Wiley Online Library
Solid dispersions have achieved significant interest as an effective means of enhancing the
dissolution rate and thus the bioavailability of a range of weakly water‐soluble drugs. Solid …

[HTML][HTML] Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging

HS Han, SY Koo, KY Choi - Bioactive Materials, 2022 - Elsevier
Over thousands of years, natural bioactive compounds derived from plants (bioactive
phytocompounds, BPCs) have been used worldwide to address human health issues …

Novel solubility prediction models: Molecular fingerprints and physicochemical features vs graph convolutional neural networks

S Lee, M Lee, KW Gyak, SD Kim, MJ Kim, K Min - ACS omega, 2022 - ACS Publications
Predicting both accurate and reliable solubility values has long been a crucial but
challenging task. In this work, surrogated model-based methods were developed to …

The Photosensitizer Temoporfin (mTHPC) – Chemical, Pre‐clinical and Clinical Developments in the Last Decade

A Wiehe, MO Senge - Photochemistry and Photobiology, 2023 - Wiley Online Library
This review follows the research, development and clinical applications of the
photosensitizer 5, 10, 15, 20‐tetra (m‐hydroxyphenyl) chlorin (m THPC, temoporfin) in …

Nanostructured lipid carriers: versatile oral delivery vehicle

N Poonia, R Kharb, V Lather, D Pandita - Future science OA, 2016 - Taylor & Francis
Oral delivery is the most accepted and economical route for drug administration and leads to
substantial reduction in dosing frequency. However, this route still remains a challenge for …

In silico evaluation of food‐derived carotenoids against SARS‐CoV‐2 drug targets: Crocin is a promising dietary supplement candidate for COVID‐19

S Mujwar, L Sun, O Fidan - Journal of Food Biochemistry, 2022 - Wiley Online Library
The current COVID‐19 pandemic is severely threatening public healthcare systems around
the globe. Some supporting therapies such as remdesivir, favipiravir, and ivermectin are still …

Nanonization techniques to overcome poor water-solubility with drugs

FLO Da Silva, MBDF Marques, KC Kato… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction Most drugs used in therapy have low water-solubility, a factor that could reduce
their dissolution rate and oral bioavailability, representing a challenge in pharmaceutical …

Supercritical antisolvent process for pharmaceutical applications: A review

P Franco, I De Marco - Processes, 2020 - mdpi.com
The supercritical antisolvent (SAS) technique has been widely employed in the biomedical
field, including drug delivery, to obtain drug particles or polymer-based systems of …