Self-emulsifying drug delivery system (SEDDS) is an isotropic mixture of lipid, surfactant and
co-surfactant, which forms a fine emulsion when comes in contact of an aqueous medium …

Apparently, tubulin inhibitors binding to the colchicine-binding site (CBS) currently have
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …

The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …

Polymorphism is the ability of solid materials to exist in two or more crystalline forms with
different arrangements or conformations of the constituents in the crystal lattice. These …

In the current study, the solubility of famotidine (FAM) in supercritical carbon dioxide
(scCO₂) was experimentally determined for the first time. The FAM solubility in scCO₂ …

Curcumin, a primary active element of turmeric, has potent antioxidant and anti-inflammatory
activity, but its low bioavailability is a major hurdle in its pharmaceutical applications. To …

Herein, a new series of cyclopentaquinoline derivatives (6a–g) were designed and
synthesized based on the pharmacophoric features acquired by some reported DNA …

The rectal route is an effective route for the local and systemic delivery of active
pharmaceutical ingredients. The environment of the rectum is relatively constant with low …

Isoliquiritigenin (ISL) is a natural medicinal product with extensive pharmacological
activities. However, its low solubility limits its application. Therefore, this study aimed to …

Purpose The present study was intended to fabricate chitosan (Ch)-tamarind gum
polysaccharide (TGP) polyelectrolyte complex stabilized cubic nanoparticles of simvastatin …