The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …

Objective To determine mechanisms underlying regional vulnerability to infarction in sickle
cell disease (SCD) by measuring voxel-wise cerebral blood flow (CBF), oxygen extraction …

The plateau is a special environment with low air pressure and low oxygen content. The
average altitude of Qinghai-Tibet is 3,500 m, and the atmospheric oxygen partial pressure in …

The aim of the present study was to examine changes in cerebral metabolism by magnetic
resonance imaging of healthy subjects during inhalation of 10% O2 hypoxic air. Hypoxic …

Key points Cognitive performance is impaired by hypoxia despite global cerebral oxygen
delivery and metabolism being maintained. Using arterial spin labelled (ASL) magnetic …

New Findings What is the central question of this study? Hypoxia associated with ascent to
high altitude may threaten cerebral oxygen delivery. We sought to determine whether there …

New Findings What is the central question of this study? What are the independent effects of
hypoxia and hypocapnia on cerebral haemodynamics and cognitive function? What is the …

Symptoms of acute mountain sickness (AMS) may appear above 2,500 m altitude, if the time
allowed for acclimatization is insufficient. As the mechanisms underlying brain adaptation to …

Key points The present study describes the cerebral oxidative and non‐oxidative
metabolism in man during a prolonged apnoea (ranging from 3 min 36 s to 7 min 26 s) that …

Abstract Study Objectives Obstructive sleep apnea (OSA) is associated with increased risk of
stroke but the underlying mechanism is poorly understood. We suspect that the normal …