Mitochondrial cytochrome c oxidase biogenesis: Recent developments
Mitochondrial cytochrome c oxidase (COX) is the primary site of cellular oxygen
consumption and is essential for aerobic energy generation in the form of ATP. Human COX …
consumption and is essential for aerobic energy generation in the form of ATP. Human COX …
[PDF][PDF] The protein import machinery of mitochondria—a regulatory hub in metabolism, stress, and disease
Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They
import more than 1,000 different proteins from the cytosol. It had been assumed that the …
import more than 1,000 different proteins from the cytosol. It had been assumed that the …
[PDF][PDF] Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPRmt
Mitochondrial diseases and aging are associated with defects in the oxidative
phosphorylation machinery (OXPHOS), which are the only complexes composed of proteins …
phosphorylation machinery (OXPHOS), which are the only complexes composed of proteins …
Mitochondria—Striking a balance between host and endosymbiont
RJ Youle - Science, 2019 - science.org
BACKGROUND Evolution generally trundles along by selecting for mutations or by
leveraging the new realms generated from chromosomal amplifications and the transfer of …
leveraging the new realms generated from chromosomal amplifications and the transfer of …
Organization and regulation of mitochondrial protein synthesis
M Ott, A Amunts, A Brown - Annual review of biochemistry, 2016 - annualreviews.org
Mitochondria are essential organelles of endosymbiotic origin that are responsible for
oxidative phosphorylation within eukaryotic cells. Independent evolution between species …
oxidative phosphorylation within eukaryotic cells. Independent evolution between species …
Nuclear miRNA regulates the mitochondrial genome in the heart
S Das, M Ferlito, OA Kent, K Fox-Talbot… - Circulation …, 2012 - Am Heart Assoc
Rationale: Mitochondria are semiautonomous cellular organelles with their own genome,
which not only supply energy but also participate in cell death pathways. MicroRNAs …
which not only supply energy but also participate in cell death pathways. MicroRNAs …
[PDF][PDF] Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein
R Richter-Dennerlein, S Oeljeklaus, I Lorenzi… - Cell, 2016 - cell.com
Mitochondrial ribosomes translate membrane integral core subunits of the oxidative
phosphorylation system encoded by mtDNA. These translation products associate with …
phosphorylation system encoded by mtDNA. These translation products associate with …
Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2
BM Baker, AM Nargund, T Sun, CM Haynes - PLoS genetics, 2012 - journals.plos.org
Cells respond to defects in mitochondrial function by activating signaling pathways that
restore homeostasis. The mitochondrial peptide exporter HAF-1 and the bZip transcription …
restore homeostasis. The mitochondrial peptide exporter HAF-1 and the bZip transcription …
Mitochondrial genetics
PF Chinnery, G Hudson - British medical bulletin, 2013 - academic.oup.com
Introduction In the last 10 years the field of mitochondrial genetics has widened, shifting the
focus from rare sporadic, metabolic disease to the effects of mitochondrial DNA (mtDNA) …
focus from rare sporadic, metabolic disease to the effects of mitochondrial DNA (mtDNA) …
OXPHOS mutations and neurodegeneration
WJH Koopman, F Distelmaier, JAM Smeitink… - The EMBO …, 2013 - embopress.org
Mitochondrial oxidative phosphorylation (OXPHOS) sustains organelle function and plays a
central role in cellular energy metabolism. The OXPHOS system consists of 5 multisubunit …
central role in cellular energy metabolism. The OXPHOS system consists of 5 multisubunit …