Cytochrome c oxidase, the terminal enzyme of the respiratory chain, is assembled from
mitochondria-and nuclear-encoded subunits. The MITRAC complex represents the central …

In bacteria, copper (Cu) is often recognised for its potential toxicity and its antibacterial
activity is now considered a key component of the mammalian innate immune system. Cu …

The coding regions of many mitochondrial genes in plants are interrupted by intervening
sequences that are classified as group II introns. Their splicing is essential for the …

N-terminal targeting signals (presequences) direct proteins across the TOM complex in the
outer mitochondrial membrane and the TIM23 complex in the inner mitochondrial …

Mitochondria maintained a genome during evolution to synthesize core subunits of the
oxidative phosphorylation system. Expression of the mitochondrial genome requires …

Alzheimer's disease (AD) is one of the most devastating neurodegenerative diseases in
modern society because of insurmountable difficulties in early diagnosis and lack of …

This novel text provides a concise synthesis of how the interactions between mitochondrial
and nuclear genes have played a major role in shaping the ecology and evolution of …

Mitochondrial respiratory chain complexes convert chemical energy into a membrane
potential by connecting electron transport with charge separation. Electron transport relies …

Three mitochondria-encoded subunits form the catalytic core of cytochrome c oxidase, the
terminal enzyme of the respiratory chain. COX1 and COX2 contain heme and copper redox …

Mitochondria are dynamic, semi-autonomous organelles that execute numerous life-
sustaining tasks in eukaryotic cells. Functioning of mitochondria depends on the adequate …