Missing data and technical variability in single-cell RNA-sequencing experiments
Until recently, high-throughput gene expression technology, such as RNA-Sequencing
(RNA-seq) required hundreds of thousands of cells to produce reliable measurements …
(RNA-seq) required hundreds of thousands of cells to produce reliable measurements …
Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation
Abstract Analysis of chromatin accessibility can reveal transcriptional regulatory sequences,
but heterogeneity of primary tissues poses a significant challenge in mapping the precise …
but heterogeneity of primary tissues poses a significant challenge in mapping the precise …
[HTML][HTML] Single-cell analysis of chromatin accessibility in the adult mouse brain
Recent advances in single-cell technologies have led to the discovery of thousands of brain
cell types; however, our understanding of the gene regulatory programs in these cell types is …
cell types; however, our understanding of the gene regulatory programs in these cell types is …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
[HTML][HTML] Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
J Carlevaro-Fita, A Lanzós, L Feuerbach… - Communications …, 2020 - nature.com
Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating
the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains …
the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains …
Functional classification of long non-coding RNAs by k-mer content
The functions of most long non-coding RNAs (lncRNAs) are unknown. In contrast to proteins,
lncRNAs with similar functions often lack linear sequence homology; thus, the identification …
lncRNAs with similar functions often lack linear sequence homology; thus, the identification …
ReMap 2018: an updated atlas of regulatory regions from an integrative analysis of DNA-binding ChIP-seq experiments
J Chèneby, M Gheorghe, M Artufel… - Nucleic acids …, 2018 - academic.oup.com
With this latest release of ReMap (http://remap. cisreg. eu), we present a unique collection of
regulatory regions in human, as a result of a large-scale integrative analysis of ChIP-seq …
regulatory regions in human, as a result of a large-scale integrative analysis of ChIP-seq …
Xenbase: a genomic, epigenomic and transcriptomic model organism database
Abstract Xenbase (www. xenbase. org) is an online resource for researchers utilizing
Xenopus laevis and Xenopus tropicalis, and for biomedical scientists seeking access to data …
Xenopus laevis and Xenopus tropicalis, and for biomedical scientists seeking access to data …
[HTML][HTML] An atlas of gene regulatory elements in adult mouse cerebrum
The mammalian cerebrum performs high-level sensory perception, motor control and
cognitive functions through highly specialized cortical and subcortical structures. Recent …
cognitive functions through highly specialized cortical and subcortical structures. Recent …
[HTML][HTML] Identifying cis elements for spatiotemporal control of mammalian DNA replication
The temporal order of DNA replication (replication timing [RT]) is highly coupled with
genome architecture, but cis-elements regulating either remain elusive. We created a series …
genome architecture, but cis-elements regulating either remain elusive. We created a series …