In embryonic stem cells (ESCs), developmental gene promoters are characterized by their
bivalent chromatin state, with simultaneous modification by MLL2 and Polycomb complexes …

Xist RNA has been established as the master regulator of X‐chromosome inactivation (XCI)
in female eutherian mammals, but its mechanism of action remains unclear. By creating …

Bioinformatics pipelines are essential in the analysis of genomic and transcriptomic data
generated by next-generation sequencing (NGS). Recent guidelines emphasize the need …

Rationale: AngII (angiotensin II)-mediated vascular smooth muscle cell (VSMC) dysfunction
plays a major role in hypertension. Long noncoding RNAs have elicited much interest, but …

MicroRNAs are short RNAs that serve as regulators of gene expression and are essential
components of normal development as well as modulators of disease. MicroRNAs generally …

Abstract The APPRIS database (http://appris-tools. org) uses protein structural and functional
features and information from cross-species conservation to annotate splice isoforms in …

Polynesia was settled in a series of extraordinary voyages across an ocean spanning one
third of the Earth, but the sequences of islands settled remain unknown and their timings …

The noncoding genome is substantially larger than the protein-coding genome but has been
largely unexplored by genetic association studies. Here, we performed region-based rare …

Meiosis, although essential for reproduction, is also variable and error-prone: rates of
chromosome crossover vary among gametes, between the sexes, and among humans of the …

The physiological relevance of structures within mammalian mRNAs has been elusive, as
these mRNAs are less folded in cells than in vitro and have predicted secondary structures …