CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …

While transport processes for amino acids and glucose have long been known to be
expressed in the luminal and abluminal membranes of the endothelium comprising the …

Introduction: It is known that the metabolic disorder caused by high glucose is one of
pathogenesis in diabetic retinopathy (DR), the leading cause of blindness, due to the main …

Aims/hypothesis Neurodegenerative changes in the diabetic retina occurring before diabetic
retinopathy could be inevitable by the altered energy (glucose) metabolism, in the sense that …

Monosaccharides enter cells by slow translipid bilayer diffusion by rapid, protein-mediated,
cation-dependent cotransport and by rapid, protein-mediated equilibrative transport. This …

For several decades the pathobiology of diabetic retinopathy has been the object of
conjecture and hypotheses. Indeed, very little was known about the cellular events triggered …

Transport of glucose into most mammalian cells and tissues is rate-controlling for its
metabolism. Glucose transport is acutely stimulated by hypoxic conditions, and the response …

Neural tissue is entirely dependent on glucose for normal metabolic activity. Since glucose
stores in the brain and retina are negligible compared to glucose demand, metabolism in …

Scientific evidence has established several links between metabolic and neurocognitive
dysfunction, and epidemiologic evidence has revealed an increased risk of Alzheimer's …

Immunogold electron microscopy has identified a variety of blood-brain barrier (BBB)
proteins with transporter and regulatory functions. For example, isoforms of the glucose …