[HTML][HTML] Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration
DJ Hellenbrand, CM Quinn, ZJ Piper… - Journal of …, 2021 - Springer
Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a
loss of motor and sensory function. Although extensive research to develop treatments for …
loss of motor and sensory function. Although extensive research to develop treatments for …
[HTML][HTML] Spinal cord injury: molecular mechanisms and therapeutic interventions
X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …
The challenges of SCI repair include its complex pathological mechanisms and the …
[HTML][HTML] Microglia coordinate cellular interactions during spinal cord repair in mice
Traumatic spinal cord injury (SCI) triggers a neuro-inflammatory response dominated by
tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated …
tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated …
[HTML][HTML] The role of macrophage subtypes and exosomes in immunomodulation
Macrophages are influential members of the innate immune system that can be reversibly
polarized by different microenvironment signals. Cell polarization leads to a wide range of …
polarized by different microenvironment signals. Cell polarization leads to a wide range of …
[HTML][HTML] Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms
A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …
socioeconomic implications for patients and their care-givers. Recent advances in medical …
[HTML][HTML] Moving beyond the glial scar for spinal cord repair
EJ Bradbury, ER Burnside - Nature communications, 2019 - nature.com
Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …
triggers a complex cascade of inflammatory and pathological processes, culminating in …
M2b macrophage polarization and its roles in diseases
L Wang, S Zhang, H Wu, X Rong… - Journal of leukocyte …, 2019 - academic.oup.com
Macrophages play an important role in a wide variety of physiologic and pathologic
processes. Plasticity and functional polarization are hallmarks of macrophages …
processes. Plasticity and functional polarization are hallmarks of macrophages …
The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities
X He, Y Li, B Deng, A Lin, G Zhang, M Ma… - Cell …, 2022 - Wiley Online Library
Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …
the injured segment of the spinal cord, which significantly impacts the quality of life in …
[HTML][HTML] Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury
C Li, Z Wu, L Zhou, J Shao, X Hu, W Xu… - Signal transduction and …, 2022 - nature.com
Spinal cord injury (SCI) involves diverse injury responses in different cell types in a
temporally and spatially specific manner. Here, using single-cell transcriptomic analyses …
temporally and spatially specific manner. Here, using single-cell transcriptomic analyses …
[HTML][HTML] Spinal cord injury scarring and inflammation: therapies targeting glial and inflammatory responses
MB Orr, JC Gensel - Neurotherapeutics, 2018 - Elsevier
Deficits in neuronal function are a hallmark of spinal cord injury (SCI) and therapeutic efforts
are often focused on central nervous system (CNS) axon regeneration. However, secondary …
are often focused on central nervous system (CNS) axon regeneration. However, secondary …