[HTML][HTML] Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine

R Singhal, YM Shah - Journal of Biological Chemistry, 2020 - ASBMB
The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species

AA Parkhitko, P Jouandin, SE Mohr, N Perrimon - Aging cell, 2019 - Wiley Online Library
Methionine restriction (MetR) extends lifespan across different species and exerts beneficial
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …

[HTML][HTML] N-acetyl cysteine functions as a fast-acting antioxidant by triggering intracellular H2S and sulfane sulfur production

D Ezeriņa, Y Takano, K Hanaoka, Y Urano, TP Dick - Cell chemical biology, 2018 - cell.com
The cysteine prodrug N-acetyl cysteine (NAC) is widely used as a pharmacological
antioxidant and cytoprotectant. It has been reported to lower endogenous oxidant levels and …

Redox-based reagents for chemoselective methionine bioconjugation

S Lin, X Yang, S Jia, AM Weeks, M Hornsby, PS Lee… - Science, 2017 - science.org
Cysteine can be specifically functionalized by a myriad of acid-base conjugation strategies
for applications ranging from probing protein function to antibody-drug conjugates and …

[HTML][HTML] Mitochondrial dysfunction remodels one-carbon metabolism in human cells

XR Bao, SE Ong, O Goldberger, J Peng, R Sharma… - elife, 2016 - elifesciences.org
Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from
rare, inborn errors of metabolism to common, age-associated diseases such as …

The chemistry of protein oxidation in food

M Hellwig - Angewandte Chemie International Edition, 2019 - Wiley Online Library
Oxidation is one of the deterioration reactions of proteins in food, the importance of which is
comparable to others such as Maillard, lipation, or protein‐phenol reactions. While research …

Role of environmental factors in shaping the soil microbiome

W Islam, A Noman, H Naveed, Z Huang… - … Science and Pollution …, 2020 - Springer
The soil microbiome comprises one of the most important and complex components of all
terrestrial ecosystems as it harbors millions of microbes including bacteria, fungi, archaea …

[HTML][HTML] Hydrogen sulfide: from a toxic molecule to a key molecule of cell life

A Aroca, C Gotor, DC Bassham, LC Romero - Antioxidants, 2020 - mdpi.com
Hydrogen sulfide (H2S) has always been considered toxic, but a huge number of articles
published more recently showed the beneficial biochemical properties of its endogenous …

Hydrogen Sulfide Generated by l-Cysteine Desulfhydrase Acts Upstream of Nitric Oxide to Modulate Abscisic Acid-Dependent Stomatal Closure

D Scuffi, C Álvarez, N Laspina, C Gotor… - Plant …, 2014 - academic.oup.com
Abscisic acid (ABA) is a well-studied regulator of stomatal movement. Hydrogen sulfide
(H2S), a small signaling gas molecule involved in key physiological processes in mammals …

Biological chemistry of hydrogen sulfide and persulfides

E Cuevasanta, MN Möller, B Alvarez - Archives of biochemistry and …, 2017 - Elsevier
Hydrogen sulfide (H 2 S) has been traditionally considered to be a toxic molecule for
mammals. However, it can be formed endogenously and exert physiological effects with …