Development of natural products for anti-PD-1/PD-L1 immunotherapy against cancer

MH Ri, J Ma, X Jin - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance The programmed cell death protein 1 (PD-1)/programmed
death-ligand 1 (PD-L1) immune checkpoint is one of the most promising therapeutic targets …

Systems pharmacology reveals the mechanism of Astragaloside IV in improving immune activity on cyclophosphamide-induced immunosuppressed mice

J Yao, J Liu, Y He, L Liu, Z Xu, X Lin, N Liu… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Myelosuppression, also known as bone marrow
suppression (BMS), is a pathological phenomenon of the decrease in the production of …

Unraveling the Pathogenesis of Myelosuppression and Therapeutic Potential of Natural Products

Q Nian, R Liu, J Zeng - Phytomedicine, 2024 - Elsevier
Background Myelosuppression is a serious and common complication of radiotherapy and
chemotherapy in cancer patients and is characterized by a reduction of peripheral blood …

Danggui Buxue decoction alleviates cyclophosphamide-induced myelosuppression by regulating β-hydroxybutyric acid metabolism and suppressing oxidative stress

Y Gao, Y Zhang, W Liu, N Zhang, Q Gao… - Pharmaceutical …, 2023 - Taylor & Francis
Abstract Context Danggui Buxue Decoction (DBD) is an effective complementary medicine
in alleviating myelosuppression after chemotherapy (MAC). However, its mechanism of …

Vitexin-2-O-rhamnoside improves immunosuppression, oxidative stress, and phosphorylation of PI3K/Akt signal pathway in cyclophosphamide treated mice

Y Wang, W Ni, X Jin, J Li, Y Yu - European journal of pharmacology, 2022 - Elsevier
Abstract Vitexin-2-O-rhamnoside (VR) is an important active substance in hawthorn, which is
widely used as a food or functional food raw material; however, its immunomodulatory …

Two birds with one stone: YQSSF regulates both proliferation and apoptosis of bone marrow cells to relieve chemotherapy-induced myelosuppression

M Zeng, Y Zhang, X Zhang, W Zhang, Q Yu… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Yiqi Shengsui formula (YQSSF) is a commonly
used formula to treat chemotherapy-induced myelosuppression, but little is known about its …

[Retracted] Effect of Shenqi Fuzheng Injection on Leukopenia and T‐cell Subsets in Patients with Non‐small Cell Lung Cancer Undergoing Radiotherapy

C Wu, Y Liang, F Fu - Evidence‐Based Complementary and …, 2022 - Wiley Online Library
Purpose. The aim of this study is to evaluate the effect of Shenqi fuzheng injection on
leukopenia and T‐cell subsets in patients with non‐small cell lung cancer (NSCLC) …

[HTML][HTML] Combined treatment (ultraviolet-C/physapruin A) enhances antiproliferation and oxidative-stress-associated mechanism in oral cancer cells

SY Peng, CY Yen, TH Lan, JH Jeng, JY Tang… - Antioxidants, 2022 - mdpi.com
Physapruin A (PHA), a Physalis peruviana-derived withanolide, exhibits antiproliferation
activity against oral and breast cancer cells. However, its potential antitumor effects in …

Human Serum Albumin Nanoparticles as a Carrier of 20(S)-Protopanaxadiol via Intramuscular Injection to Alleviate Cyclophosphamide-Induced Myelosuppression

L Liu, B Yang, H Yuan, N Yu, Y Feng… - Molecular …, 2023 - ACS Publications
Myelosuppression is a prevalent and potentially life-threatening side effect during
chemotherapy. As the main active component of ginseng, 20 (S)-protopanaxadiol (PPD) is …

What the microscale systems “see” in biological assemblies: cells and viruses?

T Hong, X Liu, Q Zhou, Y Liu, J Guo, W Zhou… - Analytical …, 2021 - ACS Publications
Miniaturization presents a prospective trend in modern analytical chemistry based on its
specific advantages, including low reagent consumption, high separation efficiency, and fast …