Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a
monogenic disease of adulthood caused by somatic mutations in UBA1 in hematopoietic …

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …

As one of the most induced genes in activated macrophages, immune-responsive gene 1
(IRG1) encodes a mitochondrial metabolic enzyme catalysing the production of itaconic acid …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Somatic mutations commonly occur in hematopoietic stem cells (HSCs). Some mutant
clones outgrow through clonal hematopoiesis (CH) and produce mutated immune progenies …

Clonal hematopoiesis resulting from the enhanced fitness of mutant hematopoietic stem
cells (HSC) associates with both favorable and unfavorable health outcomes related to the …

Aging is a universal biological process that increases the risk of multiple diseases including
cancer. Growing evidence shows that alterations in the genome and epigenome, driven by …

Inflammation-adapted hematopoietic stem and progenitor cells (HSPCs) have long been
appreciated as key drivers of emergency myelopoiesis, thereby enabling the bone marrow …

Chronic inflammation with aging (“inflammaging”) plays a prominent role in the
pathogenesis of myeloid malignancies. Aberrant inflammatory activity affects many different …