Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease

LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

Alternative lifestyles: the population structure of Trypanosoma cruzi

NR Sturm, DA Campbell - Acta tropica, 2010 - Elsevier
The genetic palette from which the spectrum of variability in Trypanosoma cruzi has been
drawn is astonishingly limited. In this review we address the roots of this unusual pedigree …

A new genotype of Trypanosoma cruzi associated with bats evidenced by phylogenetic analyses using SSU rDNA, cytochrome b and Histone H2B genes and …

A Marcili, L Lima, M Cavazzana, ACV Junqueira… - Parasitology, 2009 - cambridge.org
We characterized 15 Trypanosoma cruzi isolates from bats captured in the Amazon, Central
and Southeast Brazilian regions. Phylogenetic relationships among T. cruzi lineages using …

Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral …

A Marcili, VC Valente, SA Valente… - International journal for …, 2009 - Elsevier
In this study, we provide phylogenetic and biogeographic evidence that the Trypanosoma
cruzi lineages T. cruzi I (TCI) and T. cruzi IIa (TCIIa) circulate amongst non-human primates …

Comparative phylogeography of Trypanosoma cruzi TCIIc: new hosts, association with terrestrial ecotopes, and spatial clustering

A Marcili, L Lima, VC Valente, SA Valente… - Infection, Genetics and …, 2009 - Elsevier
We characterized 28 new isolates of Trypanosoma cruzi IIc (TCIIc) of mammals and
triatomines from Northern to Southern Brazil, confirming the widespread distribution of this …

[HTML][HTML] Geographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages

A Izeta-Alberdi, CN Ibarra-Cerdeña, DA Moo-Llanes… - Parasites & …, 2016 - Springer
Background The evolutionary history and ecological associations of Trypanosoma cruzi, the
need to identify genetic markers that can distinguish parasite subpopulations, and …

Reconsideration of the seven discrete typing units within the species Trypanosoma cruzi, a new proposal of three reliable mitochondrial clades

C Barnabé, HI Mobarec, MR Jurado, JA Cortez… - Infection, Genetics and …, 2016 - Elsevier
It is generally acknowledged that Trypanosoma cruzi, responsible for Chagas disease, is
structured into six or seven distinct discrete typing units (DTUs), and termed TcI through TcVI …

Benefits of ascorbic acid in association with low-dose benznidazole in treatment of Chagas disease

MV Providello, ZA Carneiro, GB Portapilla… - Antimicrobial agents …, 2018 - Am Soc Microbiol
The acute phase of Chagas disease (CD) is characterized by high parasitic proliferation and
intense inflammation, exacerbating the generation of reactive oxygen species (ROS) and …

[HTML][HTML] Vector competence and feeding-excretion behavior of Triatoma rubrovaria (Blanchard, 1843) (Hemiptera: Reduviidae) infected with Trypanosoma cruzi TcVI

T Verly, S Costa, N Lima, J Mallet… - PLoS Neglected …, 2020 - journals.plos.org
Background Several studies addressed changes on the insect vector behavior due to
parasite infection, but little is known for triatomine bugs, vectors of Trypanosoma cruzi, the …

Identification of novel mammalian hosts and Brazilian biome geographic distribution of Trypanosoma cruzi TcIII and TcIV

JHS Barros, SCC Xavier, D Bilac, VS Lima, MA Dario… - Acta Tropica, 2017 - Elsevier
Trypanosoma cruzi is a parasitic protozoan responsible for Chagas disease. Seven different
Discrete Typing Units (DTUs) of T. cruzi are currently identified in nature: TcI− TcVI, and …