Survey of similarity-based prediction of drug-protein interactions
Therapeutic activity of a significant majority of drugs is determined by their interactions with
proteins. Databases of drug-protein interactions (DPIs) primarily focus on the therapeutic …
proteins. Databases of drug-protein interactions (DPIs) primarily focus on the therapeutic …
[HTML][HTML] Moringa oleifera leaf extract induces osteogenic-like differentiation of human osteosarcoma SaOS2 cells
Introduction Moringa oleifera is known as a 'natural nutrition of the tropics' because it
provides vital nutritional supplements and a variety of pharmacological benefits. The focus of …
provides vital nutritional supplements and a variety of pharmacological benefits. The focus of …
Pulsed electric fields act on tryptophan to inactivate α-amylase
A Guionet, T Fujiwara, H Sato, K Takahashi… - Journal of …, 2021 - Elsevier
Enzyme inactivation is a common industrial step of food preservation. Conventional method
is based on heating, thus reduce organoleptic property and virtues of the products. We …
is based on heating, thus reduce organoleptic property and virtues of the products. We …
[HTML][HTML] In silico analyses of a promising drug candidate for the treatment of amyotrophic lateral sclerosis targeting superoxide dismutase I protein
Amyotrophic lateral sclerosis (ALS) is the most prevalent motor neuron disorder in adults,
which is associated with a highly disabling condition. To date, ALS remains incurable, and …
which is associated with a highly disabling condition. To date, ALS remains incurable, and …
GUIDE: A GUI for automated quantum chemistry calculations
A Sarkar, L Sessa, F Marrafino… - Journal of Computational …, 2023 - Wiley Online Library
The accuracy of quantum mechanics (QM) simulations depends heavily on the quality of
initial input files. Despite the popularity of QM simulation packages, achieving precise results …
initial input files. Despite the popularity of QM simulation packages, achieving precise results …
[HTML][HTML] Evaluating biofilm inhibitory potential in fish pathogen, Aeromonas hydrophila by agricultural waste extracts and assessment of aerolysin inhibitors using in …
Aeromonas hydrophila, an opportunistic bacteria, causes several devastating diseases in
humans and animals, particularly aquatic species. Antibiotics have been constrained by the …
humans and animals, particularly aquatic species. Antibiotics have been constrained by the …
In silico screening, synthesis, characterization and biological evaluation of novel anticancer agents as potential COX-2 inhibitors
A Sahu, D Pradhan, B Veer, S Kumar, R Singh… - DARU Journal of …, 2023 - Springer
Background Cyclooxygenase enzyme is frequently overexpressed in various types of cancer
and found to play a crucial role in poor prognosis in cancer patients. In current research, we …
and found to play a crucial role in poor prognosis in cancer patients. In current research, we …
[HTML][HTML] Network pharmacology and experimental verification based research into the effect and mechanism of Aucklandiae Radix–Amomi Fructus against gastric …
S Song, J Zhou, Y Li, J Liu, J Li, P Shu - Scientific reports, 2022 - nature.com
To investigate the mechanism of the Aucklandiae Radix–Amomi Fructus (AR–AF) herb pair
in treating gastric cancer (GC) by using network pharmacology and experimental …
in treating gastric cancer (GC) by using network pharmacology and experimental …
Camellia sinensis mediated synthesis and characterization of nanoparticles and applications to control Gram-negative ESBL producing antibiotic resistant bacterial …
T Juzer, S Ranjani, S Hemalatha - Food Bioscience, 2022 - Elsevier
Camellia sinensis (tea), has numerous pharmacotherapeutic benefits. The majority of its
phytocompounds exhibit antibacterial properties, which are effective in treating a range of …
phytocompounds exhibit antibacterial properties, which are effective in treating a range of …
Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase
Abstract β-Lactam antibiotics are the most important and widely used antibacterial agents
across the world. However, the widespread dissemination of β-lactamases among …
across the world. However, the widespread dissemination of β-lactamases among …