[HTML][HTML] Molecular mechanisms of anti-inflammatory activities of the extracts of Ocimum gratissimum and Thymus vulgaris

IF Olaoye, BJ Oso, A Aberuagba - Avicenna Journal of Medical …, 2021 - ncbi.nlm.nih.gov
Background: A large body of literature suggests that the extracts of Ocimum gratissimum (O.
gratissimum) and Thymus vulgaris (T. vulgaris) play protective roles against various …

[HTML][HTML] Glycation Inhibition of Bovine Serum Albumin by Extracts of Momordica charantia L. using Spectroscopic and Computational Methods

B Oso, O Agboola, I Olaoye - Avicenna Journal of Medical …, 2023 - ncbi.nlm.nih.gov
Background: Momordica charantia (M. charantia) has been used in traditional medicine for
the management of complications associated with diabetes mellitus. Several …

Computational investigation of aphid odorant receptor structure and binding function

C Sims, DM Withall, N Oldham… - Journal of …, 2023 - Taylor & Francis
Odorant receptors (OR) play a critical role in signal transduction and olfactory recognition in
insects. Unfortunately, insect ORs are difficult to express and purify, and limited structural …

[HTML][HTML] Xanthine oxidase inhibition study of isolated secondary metabolites from Dolichandrone spathacea (Bignoniaceae): In vitro and in silico approach

DK Nguyen, TW Liu, SJ Hsu, QDT Huynh… - Saudi Pharmaceutical …, 2024 - Elsevier
Xanthine oxidase (XO) has been widely recognized as a pivotal enzyme in developing
hyperuricemia, primarily contributing to the excessive production of uric acid during purine …

[HTML][HTML] Synthesis, Anticancer Activity, and Docking Studies of Novel Hydroquinone-Chalcone-Pyrazoline Hybrid Derivatives

J Maldonado, A Oliva, L Guzmán, A Molinari… - International Journal of …, 2024 - mdpi.com
A novel series of antitumor hybrids was synthesized using 1, 4-benzohydroquinone and
chalcone, furane, or pyrazoline scaffolds. This were achieved through isosteric substitution …

Residence times for femtomolar and picomolar inhibitors of MTANs

M Brown, PC Tyler, VL Schramm - Biochemistry, 2023 - ACS Publications
5′-Methylthioadenosine nucleosidases (MTANs) catalyze the hydrolysis of 5′-substituted
adenosines to form adenine and 5-substituted ribose. Escherichia coli MTAN (Ec MTAN) …

2-Acetyl-5, 8-dihydro-6-(4-methyl-3-pentenyl)-1, 4-naphthohydroquinone-Derived Chalcones as Potential Anticancer Agents

J Maldonado, A Oliva, A Molinari, W Acevedo - Molecules, 2023 - mdpi.com
Based on previous results with benzoindazolequinone (BIZQ) and 3-methylnaphtho [2, 3-d]
isoxazole-4, 9-quinone (NIQ) derivatives, a novel series of chalcone-1, 4-naphthoquinone …

Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal

DW Yeh, C Liu, JC Hernandez, SM Tahara… - Iscience, 2023 - cell.com
The synergistic effect of alcohol and HCV mediated through TLR4 signaling transactivates
NANOG, a pluripotency transcription factor important for the stemness of tumor-initiating …

Improved spectral resolution of [13C,1H]-HSQC spectra of aromatic amino acid residues in proteins produced by cell-free synthesis from inexpensive 13C-labelled …

D Van Raad, T Huber, G Otting - Journal of Biomolecular NMR, 2023 - Springer
Cell-free protein synthesis using eCells allows production of amino acids from inexpensive
13C-labelled precursors. We show that the metabolic pathway converting pyruvate, glucose …

Proposed prototype for a quantitative biosensor for insulin detection using a liquid crystal

A Satya, A Bhattacharjee - Journal of Molecular Liquids, 2024 - Elsevier
In this paper, we present a novel approach for label-free detection of human insulin using
5CB liquid crystal (LC). Monitoring insulin levels in the body is essential for treating diseases …