A structural perspective on targeting the RTK/Ras/MAP kinase pathway in cancer

DE Heppner, MJ Eck - Protein Science, 2021 - Wiley Online Library
Precision oncology is premised on identifying and drugging proteins and pathways that
drive tumorigenesis or are required for survival of tumor cells. Across diverse cancer types …

Precision targeted therapy for EGFR mutation‐positive NSCLC: Dilemmas and coping strategies

Y Meng, R Bai, J Cui - Thoracic Cancer, 2023 - Wiley Online Library
The most common driver gene mutation in patients with non‐small‐cell lung cancer
(NSCLC) is an epidermal growth factor receptor (EGFR) mutation. With the introduction of …

Low expression of long noncoding RNA CASC2 indicates a poor prognosis and regulates cell proliferation in non-small cell lung cancer

X He, Z Liu, J Su, J Yang, D Yin, L Han, W De, R Guo - Tumor Biology, 2016 - Springer
Recently, long noncoding RNAs (lncRNAs) have been shown to have important regulatory
roles in human cancer biology. The aim of this study was to evaluate the expression and …

Tyrosine kinase inhibitor combination therapy in first-line treatment of non-small-cell lung cancer: systematic review and network meta-analysis

S Batson, SA Mitchell, R Windisch… - OncoTargets and …, 2017 - Taylor & Francis
Introduction The introduction of epidermal growth factor receptor tyrosine kinase inhibitors
(EGFR-TKIs) has improved the outlook for patients with advanced non-small-cell lung …

[HTML][HTML] Cost-effectiveness of gefitinib, icotinib, and pemetrexed-based chemotherapy as first-line treatments for advanced non-small cell lung cancer in China

S Lu, M Ye, L Ding, F Tan, J Fu, B Wu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR) are becoming the
standard treatment option for patients with advanced non-small cell lung cancer (NSCLC) …

The Tyrosine Kinase Inhibitor Gefitinib Restricts Mycobacterium tuberculosis Growth through Increased Lysosomal Biogenesis and Modulation of Cytokine Signaling

KM Sogi, KA Lien, JR Johnson, NJ Krogan… - ACS infectious …, 2017 - ACS Publications
Host-directed therapeutics have the potential to combat the global tuberculosis pandemic.
We previously identified gefitinib, an inhibitor of EGFR, as a potential host-targeted …

miR-198 targets SHMT1 to inhibit cell proliferation and enhance cell apoptosis in lung adenocarcinoma

S Wu, G Zhang, P Li, S Chen, F Zhang, J Li, C Jiang… - Tumor Biology, 2016 - Springer
MiR-198 is involved in tumorigenesis, migration, invasion, and metastasis of various
malignant cancers. However, the exact expression levels of miR-198 and the molecular …

[PDF][PDF] The use of lncRNA analysis for stratification management of prognostic risk in patients with NSCLC

CG Zhang, DD Yin, SY Sun… - Eur Rev Med Pharmacol …, 2017 - europeanreview.org
OBJECTIVE: Lung cancer is the most frequent cancer in China and worldwide. Long
noncoding RNAs (lncRNAs) have been shown to play important regulatory roles in human …

The anti‐metastatic effect of ginsenoside Rb2 in colorectal cancer in an EGFR/SOX2‐dependent manner

LTH Phi, YT Wijaya, IN Sari, YG Yang, YK Lee… - Cancer …, 2018 - Wiley Online Library
Ginsenoside Rb2, a saponin from Panax ginseng, has been shown to have many functions.
However, the effect of ginsenoside Rb2 on the metastasis of colorectal cancer (CRC) …

Recent advances in neoantigen vaccines for treating non‐small cell lung cancer

S Su, F Chen, M Xu, B Liu, L Wang - Thoracic Cancer, 2023 - Wiley Online Library
The breakthrough of programmed cell death protein 1 (PD‐1) blockade therapy has
changed the clinical treatment of non‐small cell lung cancer (NSCLC) in the past few years …