A review on microplastics and nanoplastics in the environment: Their occurrence, exposure routes, toxic studies, and potential effects on human health

S Sangkham, O Faikhaw, N Munkong, P Sakunkoo… - Marine pollution …, 2022 - Elsevier
Abstract Microplastics (MPs) and nanoplastics (NPs) are emerging environmental pollutants,
having a major ecotoxicological concern to humans and many other biotas, especially …

Penetration and translocation of functional inorganic nanomaterials into biological barriers

Y Cong, D Baimanov, Y Zhou, C Chen… - Advanced Drug Delivery …, 2022 - Elsevier
With excellent physicochemical properties, inorganic nanomaterials (INMs) have exhibited a
series of attractive applications in biomedical fields. Biological barriers prevent successful …

Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy

LS Richardson, AK Kammala, MM Costantine… - Lab on a Chip, 2022 - pubs.rsc.org
Objectives: To improve preclinical drug testing during pregnancy, we developed multiple
microfluidic organ-on-chip (OOC) devices that represent the structure, functions, and …

Organ-on-a-chip technology for the study of the female reproductive system

RE Young, DD Huh - Advanced drug delivery reviews, 2021 - Elsevier
Over the past decade, organs-on-a-chip and microphysiological systems have emerged as a
disruptive in vitro technology for biopharmaceutical applications. By enabling new …

Developmental transcriptomic patterns can be altered by transgenic overexpression of Uty

KD Rock, LM Folts, HC Zierden, R Marx-Rattner… - Scientific reports, 2023 - nature.com
The genetic material encoded on X and Y chromosomes provides the foundation by which
biological sex differences are established. Epigenetic regulators expressed on these sex …

[HTML][HTML] Healthy and diseased placental barrier on-a-chip models suitable for standardized studies

G Rabussier, I Bünter, J Bouwhuis, C Soragni… - Acta Biomaterialia, 2023 - Elsevier
Pathologies associated with uteroplacental hypoxia, such as preeclampsia are among the
leading causes of maternal and perinatal morbidity in the world. Its fundamental …

Next generation strategies for preventing preterm birth

HC Zierden, RL Shapiro, K DeLong, DM Carter… - Advanced drug delivery …, 2021 - Elsevier
Preterm birth (PTB) is defined as delivery before 37 weeks of gestation. Globally, 15 million
infants are born prematurely, putting these children at an increased risk of mortality and …

Perspectives on the technological aspects and biomedical applications of virus‐like particles/nanoparticles in reproductive biology: insights on the medicinal and …

V Chandrasekar, AV Singh… - Advanced …, 2022 - Wiley Online Library
Increasing data on the infection indicate that maternal infections are severe. Under the
realms of vaccine development, virus‐like particles (VLP)/nanoparticles (NPs) hold the …

Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy

HC Zierden, R Marx-Rattner, KD Rock… - Scientific reports, 2023 - nature.com
Homeostatic regulation of the maternal milieu during pregnancy is critical for maternal and
fetal health. The placenta facilitates critical communication between maternal and fetal …

Research on nanoparticles in human perfused placenta: State of the art and perspectives

L Aengenheister, RR Favaro, DM Morales-Prieto… - Placenta, 2021 - Elsevier
Increasing human exposure to nanoparticles (NPs) from various sources raises concerns for
public health, especially for vulnerable risk groups like pregnant women and their …