Pathogenesis of triple-negative breast cancer
F Derakhshan, JS Reis-Filho - Annual Review of Pathology …, 2022 - annualreviews.org
Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of
fundamentally different diseases with different histologic, genomic, and immunologic …
fundamentally different diseases with different histologic, genomic, and immunologic …
A compendium of mutational cancer driver genes
A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …
transformation. This is key to developing more efficient cancer detection methods and …
Substitution mutational signatures in whole-genome–sequenced cancers in the UK population
A Degasperi, X Zou, T Dias Amarante… - Science, 2022 - science.org
Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses,
revealing mutational signatures, imprints of DNA damage, and repair processes that have …
revealing mutational signatures, imprints of DNA damage, and repair processes that have …
Mutational signatures: emerging concepts, caveats and clinical applications
Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …
Thanks to the sheer power provided by the thousands of mutations present in each patient's …
Pan-cancer whole-genome comparison of primary and metastatic solid tumours
F Martínez-Jiménez, A Movasati, SR Brunner… - Nature, 2023 - nature.com
Metastatic cancer remains an almost inevitably lethal disease,–. A better understanding of
disease progression and response to therapies therefore remains of utmost importance …
disease progression and response to therapies therefore remains of utmost importance …
Pan-cancer landscape of homologous recombination deficiency
L Nguyen, J WM Martens, A Van Hoeck… - Nature …, 2020 - nature.com
Homologous recombination deficiency (HRD) results in impaired double strand break repair
and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar …
and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar …
Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
The genomic and immune landscape of long-term survivors of high-grade serous ovarian cancer
DW Garsed, A Pandey, S Fereday, CJ Kennedy… - Nature …, 2022 - nature.com
Fewer than half of all patients with advanced-stage high-grade serous ovarian cancers
(HGSCs) survive more than five years after diagnosis, but those who have an exceptionally …
(HGSCs) survive more than five years after diagnosis, but those who have an exceptionally …
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations
A Villani, S Davidson, N Kanwar, WW Lo, Y Li… - Nature Cancer, 2023 - nature.com
We conducted integrative somatic–germline analyses by deeply sequencing 864 cancer-
associated genes, complete genomes and transcriptomes for 300 mostly previously treated …
associated genes, complete genomes and transcriptomes for 300 mostly previously treated …
Molecular characterisation of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis
R Pinyol, S Torrecilla, H Wang, C Montironi… - Journal of …, 2021 - Elsevier
Background and Aims Non-alcoholic steatohepatitis (NASH)-related hepatocellular
carcinoma (HCC) is increasing globally, but its molecular features are not well defined. We …
carcinoma (HCC) is increasing globally, but its molecular features are not well defined. We …