Routine assessment of the hypothalamic–pituitary–adrenal axis relies on the measurement
of total serum cortisol levels. However, most cortisol in serum is bound to corticosteroid …

Glucocorticoids regulate diverse physiological functions ranging from mitosis to apoptosis,
although only one glucocorticoid receptor (GR) gene has been discovered. We report here …

Glucocorticoids are widely used in the treatment of inflammatory and other diseases.
However, high-dose or chronic administration often triggers troublesome side effects such …

Steroid hormone receptors such as the Glucocorticoid Receptor (GR) mediate transcriptional
responses to hormones and are frequently targeted in the treatment of human diseases …

Exposure of the fetus and placenta to maternal glucocorticoids is normally limited by the
placental glucocorticoid barrier, which consists primarily of placental 11β-hydroxy-steroid …

Fundamental to eukaryotic cell signaling is the regulation of protein function by directed
localization. Detection of these events has been largely qualitative owing to the limitations of …

Aging related cognitive decline is an increasing health problem but affects only a subset of
elderly humans. This research uses outbred young (Y) and aged rats. Behavioral …

The glucocorticoid receptor (GR) dynamically interacts with response elements in the mouse
mammary tumor virus (MMTV) promoter to regulate steroid-dependent transcription. In a …

Glucocorticoids are widely used to suppress inflammation and treat various immune-
mediated diseases. Some glucocorticoid receptor (GR)-regulated genes mediate the …

Background Eukaryotic gene transcription is believed to occur in either a binary or a graded
fashion. With binary induction, a transcription activator (TA) regulates the probability with …