Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

Cell-substrate interactions play a crucial role in the design of better biomaterials and
integration of implants with the tissues. Adhesion is the binding process of the cells to the …

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

Vascular diseases are the most prevalent cause of ischemic necrosis of tissue and organ,
which even result in dysfunction and death. Vascular regeneration or artificial vascular graft …

Directed migration by contact guidance is a poorly understood yet vital phenomenon,
particularly for carcinoma cell invasion on aligned collagen fibres. We demonstrate that for …

When blood first encounters the artificial surface of a medical device, a complex series of
biochemical reactions is triggered, potentially resulting in clinical complications such as …

Cells in their in vivo microenvironment constantly encounter and respond to a multitude of
signals. While the role of biochemical signals has long been appreciated, the importance of …

The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial
and mechanical cues to which cells respond. In addition to soluble chemical factors …

The current development of nanobiotechnologies requires a better understanding of cell–
surface interactions on the nanometre scale. Recently, advances in nanoscale patterning …

The interaction of cells and tissues with artificial materials designed for applications in
biotechnologies and in medicine is governed by the physical and chemical properties of the …