Glycosylation is a frequent co/post-translational modification of proteins which modulates a
variety of biological functions. The analysis of N-glycome, ie the sugar chains N-linked to …

Glycosylation is the most complex post-translational modification of proteins. Altered glycans
on the tumor-and host-cell surface and in the tumor microenvironment have been identified …

SLC39A8 is a membrane transporter responsible for manganese uptake into the cell. Via
whole-exome sequencing, we studied a child that presented with cranial asymmetry, severe …

How peroxisomes are formed in eukaryotic cells is unknown but important for insight into a
variety of diseases. Both human and yeast cells lacking peroxisomes due to mutations in …

Galactose is transferred via several linkages to acceptor structures by galactosyltransferase
enzymes. In prokaryotes, galactose is mainly found on lipopolysaccharides and capsular …

Neonates with intrauterine growth restriction (IUGR) are prone to suffer from digestive
diseases. Using neonatal pigs with IUGR, we tested the hypothesis that IUGR may induce …

Beta-1, 4-galactosylransferase (β4Gal-T1) participates in the synthesis of Galβ1-4-GlcNAc-
disaccharide unit of glycoconjugates. It is a trans-Golgi glycosyltransferase (Glyco-T) with a …

In the past decades, a large number of studies in mammalian cells have revealed that
processing of glycoproteins is compartmentalized into several subcellular organelles that …

Carbohydrates establish the third alphabet of life. As part of cellular glycoconjugates, the
glycans generate a multitude of signals in a minimum of space. The presence of distinct …

Non-alcoholic liver disease (NAFLD) is a condition caused by excessive fat accumulation in
the liver and developed via multiple pathways. miR-27b has been suggested to play crucial …