Intracerebral hemorrhage (ICH) is a subtype of stroke with a high mortality rate. Oxidative
stress cascades play an important role in brain injury after ICH. Cannabidiol, a major non …

There is an urgent need for novel fast-acting antidepressants for adolescent treatment-
resistant depression and/or suicidal risk, since the selective serotonin reuptake inhibitors …

We report a blueprint for the rational design of G protein coupled receptor (GPCR) ligands
with a tailored functional response. The present study discloses the structure-based design …

Lipoxygenases (LOXs) are a family of enzymes that includes different fatty acid oxygenases
with a common tridimensional structure. The main functions of LOXs are the production of …

Endocannabinoids modulate fear extinction controlled by a cortical-amygdala projection: Neuron
Skip to Main Content Advertisement Neuron This journal offers authors two options (open access …

Introduction Cannabinoid receptor type 2 (CB2R), predominantly expressed in immune
tissues, is believed to play a crucial role within the body's protective mechanisms. Its …

Neuroinflammation is a hallmark of several neurodegenerative disorders that has been
extensively studied in recent years. Microglia, the primary immune cells of the central …

Opioid-related overdose deaths are still on the rise in North America, emphasizing the need
to better understand the underlying neurobiological mechanisms regarding the development …

Microgravity is one of the main stressors that astronauts are exposed to during space
missions. This condition has been linked to many disorders, including those that feature …

Ischemic heart disease, associated with high morbidity and mortality, represents a major
challenge for the development of drug-based strategies to improve its prognosis. Results of …