In vitro lung models and their application to study SARS-CoV-2 pathogenesis and disease

N Heinen, M Kloehn, E Steinmann, S Pfaender - Viruses, 2021 - mdpi.com
SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has
put scientist and pharmaceutical companies worldwide on the spot to develop novel …

An in-silico study of the mutation-associated effects on the spike protein of SARS-CoV-2, Omicron variant

TA Shishir, T Jannat, IB Naser - PLoS One, 2022 - journals.plos.org
The emergence of Omicron (B. 1.1. 529), a new Variant of Concern in the COVID-19
pandemic, while accompanied by the ongoing Delta variant infection, has once again fueled …

Alveolar macrophages: Achilles' heel of SARS-CoV-2 infection

Z Wang, S Li, B Huang - Signal Transduction and Targeted Therapy, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has caused more than 6.3
million deaths to date. Despite great efforts to curb the spread of severe acute respiratory …

[HTML][HTML] From Immunogen to COVID-19 vaccines: Prospects for the post-pandemic era

G Miao, Z Chen, H Cao, W Wu, X Chu, H Liu… - Biomedicine & …, 2023 - Elsevier
The COVID-19 pandemic has affected millions of people and posed an unprecedented
burden on healthcare systems and economies worldwide since the outbreak of the COVID …

Do Changes in ACE-2 Expression Affect SARS-CoV-2 Virulence and Related Complications: A Closer Look into Membrane-Bound and Soluble Forms

HC Yalcin, V Sukumaran, MKAA Al-Ruweidi… - International Journal of …, 2021 - mdpi.com
The SARS-CoV-2 virus utilizes angiotensin converting enzyme (ACE-2) for cell entry and
infection. This enzyme has important functions in the renin-angiotensin aldosterone system …

Is there (will there be) a post-COVID-19 chronic cough?

PV Dicpinigaitis, BJ Canning - Lung, 2020 - Springer
Cough is among the most common symptoms associated with an acute viral upper
respiratory tract infection (URI; common cold). In the vast majority of afflicted persons, acute …

[HTML][HTML] Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19

W He, Y Gao, J Zhou, Y Shi, D Xia… - International Journal of …, 2022 - ncbi.nlm.nih.gov
There is increasing amount of evidence indicating the close interplays between the
replication cycle of SARS-CoV-2 and the autophagy-lysosome pathway in the host cells …

Endothelial cell activation by SARS-CoV-2 spike S1 protein: a crosstalk between endothelium and innate immune cells

BM Rotoli, A Barilli, R Visigalli, F Ferrari, V Dall'Asta - Biomedicines, 2021 - mdpi.com
Background. Emerging evidences suggest that in severe COVID-19, multi-organ failure is
associated with a hyperinflammatory state (the so-called “cytokine storm”) in combination …

Beyond energy balance regulation: The underestimated role of adipose tissues in host defense against pathogens

J Barthelemy, G Bogard, I Wolowczuk - Frontiers in Immunology, 2023 - frontiersin.org
Although the adipose tissue (AT) is a central metabolic organ in the regulation of whole-
body energy homeostasis, it is also an important endocrine and immunological organ. As an …

Importance of magnesium status in COVID-19

F Guerrero-Romero, O Micke, LE Simental-Mendía… - Biology, 2023 - mdpi.com
Simple Summary Magnesium is an essential nutrient, also called an essential mineral or
element. Magnesium is vastly important in all life, with vital roles for the healthy functioning …