18F-labelling innovations and their potential for clinical application

HH Coenen, J Ermert - Clinical and Translational Imaging, 2018 - Springer
An impressive variety of new methodologies for the preparation of 18 F-labelled tracers and
ligands has appeared over the last decade. Most strategies of the newly developed …

Phase Transfer catalysts and role of reaction environment in nucleophilc radiofluorinations in automated synthesizers

RN Krasikova, VV Orlovskaya - Applied Sciences, 2021 - mdpi.com
Incorporation of [18F] fluorine into PET radiotracer structure has traditionally been
accomplished via nucleophilic pathways. The [18F] fluoride is generated in an aqueous …

Production of diverse PET probes with limited resources: 24 18F-labeled compounds prepared with a single radiosynthesizer

J Collins, CM Waldmann, C Drake… - Proceedings of the …, 2017 - National Acad Sciences
New radiolabeled probes for positron-emission tomography (PET) are providing an ever-
increasing ability to answer diverse research and clinical questions and to facilitate the …

Chemistry considerations for the clinical translation of oncology PET radiopharmaceuticals

L Allott, EO Aboagye - Molecular Pharmaceutics, 2020 - ACS Publications
Positron emission tomography (PET) has proven to be an invaluable tool in the staging and
management of disease in oncology; however,[18F] fluorodeoxyglucose ([18F] FDG) …

PHENYX–A flexible pipetting-based platform for automated microvolume radiochemistry

Y Lu, J Wang, RM van Dam, A Hsiao - Chemical Engineering Journal, 2022 - Elsevier
Recent droplet-based radiochemistry platforms have enabled reactions in< 10 µL volumes,
providing many advantages including minimal reagent consumption, fast synthesis times …

Optimization of nucleophilic 18F radiofluorinations using a microfluidic reaction approach

G Pascali, L Matesic, TL Collier, N Wyatt, BH Fraser… - nature protocols, 2014 - nature.com
Microfluidic techniques are increasingly being used to synthesize positron-emitting
radiopharmaceuticals. Several reports demonstrate higher incorporation yields, with shorter …

Electrochemical fluorination and radiofluorination of methyl (phenylthio) acetate using tetrabutylammonium fluoride (TBAF)

M Balandeh, C Waldmann, D Shirazi… - Journal of the …, 2017 - iopscience.iop.org
Electrochemical fluorination of methyl (phenylthio) acetate was achieved using
tetrabutylammonium fluoride (TBAF). Electrochemical fluorination was performed under …

18F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases

VM Petriev, VK Tishchenko, RN Krasikova - Pharmaceutical Chemistry …, 2016 - Springer
This review addresses progress in the radionuclide diagnosis of oncological diseases using
radiopharmaceutical preparations (RPP) based on labeled glucose derivatives. Most …

18F-Labelled catecholamine type radiopharmaceuticals in the diagnosis of neurodegenerative diseases and neuroendocrine tumours: Approaches to synthesis and …

SZ Vatsadze, OE Eremina, IA Veselova… - Russian Chemical …, 2018 - iopscience.iop.org
The pathogenesis of many socially significant diseases such as neurodegenerative
dementias and neuroendocrine tumours involves imbalance of neurotransmitters. Among …

Основные проблемы обеспечения качества радиофармацевтических лекарственных препаратов

ГЕ Кодина, АО Малышева - Ведомости Научного центра …, 2019 - cyberleninka.ru
Одним из основных условий, определяющих успешное применение технологий
ядерной медицины, является получение и введение пациенту …