Metabolic reprogramming occurs in tumors to foster cancer cell proliferation, survival and
metastasis, but as well at a systemic level affecting the whole organism, eventually leading …

Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are
known to exert both pro-and anti-tumour effects. We summarize our current understanding of …

Background Cancer is a major burden of disease worldwide and increasing evidence shows
that inflammation contributes to cancer development and progression. Eicosanoids are …

Tumor growth is associated with profound metabolic and neurochemical alterations, which
can lead to the onset of anorexia–cachexia syndrome. Anorexia is defined as the loss of the …

L-Arginine (Arg) is classified as an essential amino acid for birds, carnivores and young
mammals and a conditionally essential amino acid for adults. It is converted by arginase to L …

Purpose The diatomic radical nitric oxide (NO) has been the cause of intense debate with
implication in carcinogenesis, tumour progression, invasion, angiogenesis and modulation …

Anorexia and reduced food intake are important issues in the management of patients with
cancer because they contribute to the development of malnutrition, increase morbidity and …

Mrs MJ is a 56-year-old architect with a husband and two children. You performed a
mastectomy and axillary dissection on her after neoadjuvant chemotherapy for locally …

Abstract Cyclooxygenase (COX)-2 is an inducible enzyme involved in production of
prostaglandins in inflammatory processes. There is now increasing evidence that a …

With a constantly increasing incidence, cutaneous melanoma has raised the need for a
better understanding of its complex microenvironment that may further guide therapeutic …