The genomes of influenza viruses consist of multiple segments of single-stranded negative-
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Highlights•Coronavirus nucleocapsid proteins are appealing drug targets against
coronavirus-induced diseases.•A variety of compounds targeting the coronavirus …

Influenza viruses (IVs) are a continual threat to global health. The high mutation rate of the IV
genome makes this virus incredibly successful, genetic drift allows for annual epidemics …

Abstract The Coronavirus Disease 2019, caused by the severe acute respiratory syndrome
coronavirus 2 is an exceptionally contagious disease that leads to global epidemics with …

The outbreak of COVID-19 caused by SARS-CoV-2 virus continually led to infect a large
population worldwide. Currently, there is no specific viral protein-targeted therapeutics. The …

Influenza virus (IFV) causes periodic global influenza pandemics, resulting in substantial
socioeconomic loss and burden on medical facilities. Yearly variation in the effectiveness of …

Prevention and treatment of influenza virus infection is an ongoing unmet medical need.
Each year, thousands of deaths and millions of hospitalizations are attributed to influenza …

Introduction: Seasonal influenza and pandemic outbreaks typically result in high mortality
and morbidity associated with severe economic burdens. Vaccines and anti-influenza drugs …

The influenza virus is responsible for millions of cases of severe illness annually. Yearly
variance in the effectiveness of vaccination, coupled with emerging drug resistance …