Background Iron is essential for many types of biological processes. However, excessive
iron can be cytotoxic and can lead to many diseases. Since ferroptosis, which is an iron …

This review explores the multifaceted role that iron has in cancer biology. Epidemiological
studies have demonstrated an association between excess iron and increased cancer …

Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also
has the capacity to engage in redox cycling and free radical formation. Therefore, iron can …

Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron
metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria …

Breast cancer has become a serious threat to women's health. Cancer progression is mainly
derived from resistance to apoptosis induced by procedures or therapies. Therefore, new …

Iron has been suggested as a risk factor for different types of cancers mainly due to its
prooxidant activity, which can lead to oxidative DNA damage. Furthermore, subjects with …

Iron plays an essential role in normal biological processes: The generation of cellular
energy, oxygen transport, DNA synthesis and repair are all processes that require iron …

Iron is an essential nutrient that is tightly regulated. A principal function of the liver is the
regulation of iron homeostasis. The liver senses changes in systemic iron requirements and …

Iron is critical to the survival of almost all living organisms. However, inappropriately low or
high levels of iron are detrimental and contribute to a wide range of diseases. Recent …

Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of
oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute …